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General Surgery > Inflammatory bowel disease > Flashcards

Inflammatory bowel disease Flashcards

1
Q

Site of Crohn’s disease

A

Entire GI tract

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2
Q

Inflammation pattern of Crohn’s disease

A

Transmural

Skip lesions

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3
Q

Microscopic appearance of Crohn’s disease

A

Non-caseating granulomatous inflammation

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4
Q

Macroscopic appearance of Crohn’s disease

A

Skip lesions
cobblestone appearance
fistula formation

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5
Q

Risk factors of Crohn’s disease

A

Family history

Smoking

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6
Q

Clinical features of Crohn’s disease

A 
Abdominal pain
Diarrhoea
Mouth ulcers
Peri-anal disease
Skin 
- erythema nodosum
- pyoderma gangrenosum
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7
Q

Investigations for suspected Crohn’s disease

A

Bloods

  • anaemia
  • low albumin
  • raised CRP/WCC

Colonoscopy

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8
Q

How do you induce remission in Crohn’s?

A

Steroids

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9
Q

Site of ulcerative colitis

A

Large bowel

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10
Q

Inflammation pattern of ulcerative colitis

A

Mucosa only

Continuous inflammation

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11
Q

Microscopic changes in ulcerative colitis

A

Crypt abscesses
Reduced goblet cells
non-granulomatous

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12
Q

Macroscopic changes in ulcerative colitis

A 
Continuous inflammation (proximal from rectum)
Pseudopolyps
Ulcers
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13
Q

Clinical features of ulcerative colitis

A 
Bloody diarrhoea
Proctitis
PR bleeding 
Mucus discharge
Clubbing
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14
Q

Investigations for suspected ulcerative colitis

A

Bloods

  • anaemia
  • low albumin
  • raised CRP/WCC

Faecal calprotectin
Stool sample
Colonoscopy

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15
Q

How do you induce remission in UC?

A

Steroids

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16
Q

What is toxic megacolon?

A

Inflammation and distension of colon

Presents with severe abdo pain, abdo distension and pyrexia

Reuquires decompression ASAP due to risk of perforation

17
Q

How do you maintain remission in Crohn’s?

A

Azathioprine
Infliximab
Adulimab

18
Q

How do you maintain remission in UC?

A

Mesalzine
Azathioprine
Biologics

General Surgery (15 decks)

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