Inflammatory Bowel Disease

Question 1

What disease is associated with granulomas?

Answer 1

Crohn’s ==> Granulomas

Question 2

What disease is not associated with granulomas?

Answer 2

UC ==> NOT GRANULOMAS

Question 3

what disease affects the colon + rarely terminal ileum

Answer 3

UC

Question 4

What disease affects mainly the illeum

Answer 4

Crohn’s

Question 5

What is the typical age of diagnosis in uc

Answer 5

15-25yr olds

Question 6

What is the main theory cause of UC + Crohn’s

Answer 6

Immune related disease that immune system attacks friendly bacteria and damages gut in process

Question 7

what is the fraction of those in the genetic pool that are connected to IBD

Answer 7

1/4 have genetic link

Question 8

4 symptoms of Crohn’s

Answer 8

Abdominal distension
Abdominal pain
Diarrhoea
Bloody stool*

*rare for blood although if crohn’s affects Large intestine its possible

Question 9

What are the 5 Signs in UC (…..)

** 1 is xray

Answer 9

5P’s

Pyrexia
Poo (bloody)
Pseudocysts
Pipe radiological appearance
Proctitis

Question 10

What test can be done to distuinguish difference between IBD / IBS

Answer 10

Neutrophil Calprotectin Test (NCT)

high in IBD

Question 11

What are 2 investigations that can be done

**IBD

Answer 11

Colonoscopy w/tissue biopsy

X-ray => Toxic megacolon + exclude perforation

Question 12

What drug can be given to both Crohn’s and UC

Answer 12

5-ASA (Sulfasalazine)

Question 13

What drug can be given to UC but not Crohn’s

Answer 13

Methotrexate*

*just less effective not toxic etc.

Question 14

What are 3 complications of UC

Answer 14

Toxic megacolon

Increased risk of colon cancer

Osteoporosis (steroid use)

Question 15

What are 5 complications of Crohn’s

Answer 15

Stricture formation

Fistula formation

Pyoderma Gangrenosum (ulcer on skin)

Anaemia

Osteoporosis