Inflammation, Regeneration, Repair (Yurchenko)

Question 1

Leukocyte Adhesion Deficiency

Answer 1

Deficiency in leukocyte adhesion due to an integrin or selectin mutation (LAD 1, 3 respectively)

Question 2

Myeloperoxidase Deficiency

Answer 2

Decreased microbial killing due to defective MPO-H2O2 system, leading to fungal infections or asymptomatic
-less severe than CGD

Question 3

Chediak-Hidashi Syndrome

Answer 3

Decreased leukocyte function due to mutation in proteins responsible for lysosomal membrane trafficking
-Causes infections, CNS issues

Question 4

Chronic Inflammation

Answer 4

Unlike Acute, angiogenesis and fibrogenesis (CT formation) take place. Fibroblast migration can cause thickening of alveoli, abscess/encapsulation/necrotic center walling off infection

Question 5

Empyema

Answer 5

Accumulation of pus in existing body cavity

Question 6

Granulatory Inflammation

Answer 6

In addition to chronic factors, need hypoxia to initiate

Question 7

VEGF

Answer 7

pro-angiogenic factor secreted by leukocytes in chronic inflammatory response

Question 8

Fibrosis

Answer 8

Caused by fibroblasts creating ton of collagen and ECM in chronic inflammatory response, then leaving acellular area

Question 9

Chronic Granulomatous Disease

Answer 9

Caused by lack of NADPH activity (decreased oxidative burst)

• male>female
• chronic, multiple infections of skin and immune tissues
• Forms granuloma, abcess, fibroblasts wall around necrotic center