Cytokines (Langer) Flashcards
1
Q
Chemokines
A
- 8-10kd (smaller than cytokines)
- Signal via GPCR (unlike protein kinases)
- Function as chemotactic
2
Q
IL-1
A
Role in inflammation
3
Q
TNF-å
A
Role in inflammation
4
Q
IL-2
A
Causes T-cell growth and division
5
Q
IFN-å
A
defense against viruses
6
Q
IFN-gamma
A
- Stimulates cell-mediated immunity (macrophages)
- produced by T-cells (TH1), NK cells
7
Q
IL-8
A
- Chemokine
- chemotaxis to site of infection or to secondary lymphoid organs
- Produced by macrophages to attract neutrophils (IL-8 = neutrophil chemotactic factor)
8
Q
TGF-ß
A
Downregulates immune response
9
Q
IL-4, IL-5
A
B-cell growth, differentiation
10
Q
IL-10
A
DOWNREGULATES immune response
11
Q
X-SCID (X-linked Severe Combined Immunodeficiency Syndrome)
A
Lack of T-cells/NK cells due to low gamma subunit production affecting a host of cytokines. Lack of both of these prevents B-cells too, so COMBINED immunodeficiency
12
Q
IL-6
A
Pro-inflammatory
13
Q
IL-12
A
Causes T-cell maturation from naive
-secreted by activated T-cell or macrophage
14
Q
TH1 Cells
A
- Secrete IFN-gamma (causing macrophage activation, IgG production)
- Role in autoimmune diseases (Nanda, TH1>TH2)
15
Q
TH2
A
- Secretes IL-4, IL-5, IL-13
- Causes Mast cell, eosinophil activation, IgE production
- Used vs. parasites
- Role in allergies
