Inflammation: pgs 4-6 Flashcards
What are the 4 latin words for the different parts of inflammation?
1) Rubor - redness
2) Dolor - pain
3) Tumor - swelling
4) Color - heat
T/F - Only certain injuries to the body results in inflammation.
False - ANY injury to the body results in inflammation. It is part of a continuum with immune response at the other end.
What are the function of inflammation?
- Remove injurious agent or limit its spread (wall it off)
- Repair the tissue and clean up the damage
What are some of the processes involved with inflammation (not necessarily at the same time or to the same extent though)?
- Vasodilation
- Histamine release
- Kinins produced
- Phagocyte migration
- Repair
- Fever
What is the purpose of vasodilation in regards to inflammation?
An increase in the permeability of the vascular wall allows plasma to come in, which contains complement and bacteriostatic agents. Also, PMNs are able to move into the interstitial space. Edema occurs.
What cells secrete histamine and what does histamine do?
Mast cells & histamine increases vascular permeability
What do kinins do?
Increase vascular permeability and summon PMNs
__________________ is the sticking of cells along the sides of a blood vessel (involved with phagocyte migration).
Margination
________________ is the movement of cells through the vascular wall.
Diapedesis
How is scarring produced?
By the stroma, the supporting connective tissue - occurs when the parenchyma cannot regenerate.
What mechanism is used to speed repair and inhibit the growth of invading microbes?
Fever
How can the presence of microbes be determined?
By looking for small scale repeating structures (due to limited genome) - PAMPs
What are PAMPs?
Pathogen associated molecular patterns
What does TLR stand for?
Toll like receptor
What does TLR-1 and TLR-2 heterodimer recognize?
Peptidoglycan
Lipoproteins
Zymosans
and Others
