Inflammation- Mesa

Question 1

Key player in acute inflammation

Answer 1

neutrophils

Question 2

Stimuli for accute inflammation

Answer 2

necrosis
foreign bodies
infection
immmune reaction

Question 3

Vasuclar changes

Answer 3

cause red color: blood flowing

also cause swollen

Question 4

Exudate

Answer 4

High Protein cells

Question 5

Transudate

Answer 5

low protein cells

Question 6

What helps with adhesion

Answer 6

integrins

secretins

Question 7

Move through wall?

Answer 7

chemoaxis

Question 8

What are 3 ways C3 can complement?

Answer 8

1. C3b can attach to Ca and stimulate inflmmation by attracting more leukocytes
2. C3b can act directly on its own and induce phagocytosis
3. C3b can gather and form MAC for cell lysis

Question 9

Bradykinin

Answer 9

PAIN

smooth muscle constricter not vascular

Question 10

Which chemical mediater pain and fever? clotting?

Answer 10

Prostaglandins

Question 11

Which are mediators are vasodilators?

Answer 11

serotonin
histamine
lipoxins
nitric oxide

Question 12

Which mediators are vasonconstrictors?

Answer 12

Leuokotrienes (maintain blood pressure)

Question 13

What stops cgemotaxis?

Answer 13

lipoxins

Question 14

Granulomatous Inflammation

Answer 14

Crohns disease
histocytes*
giant cells 
fivroblasts
lymphs

Question 15

Fibrosis as healing

Answer 15

In order for fibrosis to occur, you need t use connective tissue from ECM, which means you will have to damage ECM

Question 16

Epidermal Growth Factor

Answer 16

made in platelets and macrophages
present in saliva, milk, urine, plasma
acts on keratinocytes
acs on fibroblasts to create granulation

Question 17

T GF alpha

Answer 17

macrophages
hepatocytes
keratinocytes
t cells

Question 18

Which 3 growth factors affect the liver?

Answer 18

EGF
Hepatocyte growth factor
TGF alpha

Question 19

Hepatocyte growth factor

Answer 19

made from mesenchymal cells

prolifer of hepatocytes, endothelium, epithelium

Question 20

Vascular Endothelial

Answer 20

made by mesenchymal
key in promoting granulation
triggered by hypoxia
increase vascular permiability

Question 21

Platelet Derived GF

Answer 21

made in platelets
important for angiogenisis
key in granulation
chemotactic for many cells
mitogenic for fibroblasts (causes fibroblast to divide)

Question 22

Key GF for promoting granulation

Answer 22

VE GF

PD GF

Question 23

Fibroblast GF

Answer 23

chemotactic and mitogenic for fibroblast and keratinocytes
re- epithelialization
angiogenisis (wound)
hematopoiesis
cardiac/ skeletal muscle

Question 24

Transforming GF

Answer 24

inhibits epithelial
macrophages
stimulates progression and migration of fibroblasts
increases collagen formation
helps limit and term inflam responses

Question 25

K GF

Answer 25

made in fibroblasts