inflammation , inflammatory diseases, repair

Question 1

allows inflammatory cells, plasma proteins, and fluids to exit blood vessel and enter interstitial space

Answer 1

inflammation

Question 2

true or false
in chronic inflammation, mononucleated cells are the cellular infiltrate

Answer 2

true

Question 3

characterized by the presence of edema and neutrophils in the tissue

Answer 3

acute inflammation

Question 4

acute inflammation, cells of innate immunity are responsible. immediate response with limited specificity.
a. 1st statement is true
b. 2nd statement is true
c. both are true
d. both are false

Answer 4

c

Question 5

_______ is present on cells of innate and addaptive immune system and activated by PAMPs.

Answer 5

toll like receptors

Question 6

recognizes LPS of gram neg bacteria

Answer 6

CD14

Question 7

arachidonic acid is released from phospholipid cell membrane by phospholipase A2. it blocks cyclooxyrgenase or 5-lipooxygenase.
a. 1st statement is true
b. 2nd statement is true
c. both are true
d. both are false

Answer 7

c

Question 8

prostaglandins are produced by ________

Answer 8

cyclooxygenase

Question 9

all of the following promotes vasodilation
1. PG
2. histamine
3. serotonin
4. thromboxane

a. 2 only
b. 2,3
c. 1,2,3
d. all of the above

Answer 9

c

Question 10

complement proteins C3a and C5a produces ________ that promotes vasodilation.

Answer 10

histamine

Question 11

mast cells release histamine granules. increase vasodilation of arterioles and increased vascular permeability.
a. 1st statement is true
b. 2nd statement is true
c. both are true
d. both are false

Answer 11

c

Question 12

which of the following is incorrect?
1. alternative pathway - microbe
2. classical pathway - antibody
3. lectin pathway - MBL

a. only 3
b. 1 and 2
c. 1 and 3
d. NOTA

Answer 12

d

Question 13

complement proteins that trigger mast cell degranulation

Answer 13

C3a and C5a

Question 14

chemotactic factor for neutrophils

Answer 14

C5a

Question 15

opsonin for phagocytosis

Answer 15

C3b

Question 16

inactivate pro inflammatory protein produced in the liver

Answer 16

hageman factor

Question 17

what are the outcomes of acute Inflammation

Answer 17

1. 100% complete resolution
2. scar
3. chronic inflammation

Question 18

which of the following are stimuli of chronic inflammation
1. persistent infection
2. autoimmune disease
3. foreign materials
4. cancer

a. 123
b. 234
c. 2 and 4
d. 1,3 and 4
e. all of the above

Answer 18

E

Question 19

true or false
T cells use TCR complex for antigen surveillance

Answer 19

true

Question 20

activation of T cells requires
1. binding of antigen
2. MHC complex
3. additional 2nd signal

a. 1 and 2
b 1 and 3
c. 1 only
d. all of the above

Answer 20

d

Question 21

enumerate the 5 cardinal signs off inflammation

Answer 21

rubor
tumor
calor
dolor
functio laesa

Question 22

all of the following are key mediators od Rubor and calor except
a. histamine
b. PGs
c. TNFs
d. bradykinin

Answer 22

c

Question 23

mediators of tumor
a. histamine
b. tissue damage
c. either
d. neither

Answer 23

c

Question 24

T or F
bradykinin and PGE2 are the key mediators of Dolor

Answer 24

true

Question 25

surrounded by giant cells and rim of lymphocytes

Answer 25

granulomatous inflammation

Question 26

extensive outpouring of watery, low protein. derived from serum or secretions from serial mesothelial cells.

Answer 26

serous inflammation

Question 27

excessive discharge or build up of mucus in the nose or throat, associated with inflammation of the mucus membrane.

Answer 27

catarrhal inflammation

Question 28

enumerate the changes in cellular growth patterns

Answer 28

retrogressive progressive degenerative

Question 29

which of the following is capable of retrogressive change 1. agenesia 2. hypoplasia 3. atresia 4. atrophy 5. aplasia 6. hyperplasia a. 1234 b. 123 c. 1245 d. 12345 e. all of the above

Answer 29

d

Question 30

tumor with normal tissue or organ components that are inappropriate to surrounding tissues.

Answer 30

teratomas

Question 31

degree of cell differentiation and mitotic activity on histology. ranges from low grade to high grade or undifferentiated.

Answer 31

grading

Question 32

degree of invasion and spread from initial site

Answer 32

staging

Question 33

true or false stage generally has more prognostic value that grade

Answer 33

true

Question 34

defined as cessation of cardiopulmonary functions and/or cessation of brain activity

Answer 34

death

Question 35

Death occurs when there is deep, irreversible absence of electrical brain activity and complete cessation of the vital functions without the possibility of resuscitation.

Answer 35

brain death

Question 36

Complete, persistent and continuous cessation of the vital functions of the brain, heart and lungs which maintain life and health.

Answer 36

somatic death

Question 37

stiffening of the body parts

Answer 37

rigor mortis

Question 38

begins 2 hours after death: becomes permanent after 8hrs

Answer 38

livor mortis

Question 39

low HR, low BP, low RR

Answer 39

somatic death

Question 40

cooling of the body

Answer 40

algor mortis

Question 41

change in skin color after death

Answer 41

palor mortis

Question 42

abnormal new cell growth

Answer 42

neoplasia

Question 43

responsible for fever and pain

Answer 43

PGE2

Question 44

responsible for bronchospasm

Answer 44

b4 c4 d4 e4