Inflammation-Complimentary System

Question 1

What are complimentary protein of inflammation, made by what and how are they activated

Answer 1

• innate immune proteins made by liver and aid in immune response
• changes in vascular flow due to increased permeability

Question 2

List the 3 pathways of complimentary proteins action in immune response

Answer 2

1 classical pathway
2 lectin pathway
3 alternate pathway

Question 3

What are memory antibodies

Do they bind direct to bacteria antigen

What is a FC portion

Answer 3

• antibodies which where previously exposed to bacterial antigen
• Yes
• specific portion on memory antibody that is very attractive to complimentary proteins

Question 4

Order of which complimentary protein bind to Fc portion

Answer 4

-C1
C4
C2
C3b
C5b
C6
C7
C8
C9

Question 5

What does C3 and C5 convertase

do. How does this enhance immune response

Answer 5

• they split C3 and C5 into C3-5A and C3-5b
• C3-5A break off and protease released by mast cells actives them and they act as chemoattractants for neutrophils and macrophages

Question 6

What happens to C3-5b.

Answer 6

They stay on the complimentary protein complex

Question 7

What happens to C5B-C9 and its effects

Effect of MAC

Answer 7

• break of and form pentameric protein Membrane attack complex ( MAC )
• expose C3B
• MAC binds to bacteria membrane and allow for entry of interstitial fluid with Na+ and H2O causing lysis of bacteria

Question 8

What happens after C3b is exposed

Answer 8

-macrophages have receptors C3B receptors which bind to C3B protein enhancing phagocytosis ( making it easier for macrophages to engulf )

Question 9

What is an opsonin and opsonization

Answer 9

• a molecule which causes opsonization

- coating of bacteria to make it easier for WBC’s to engulf bacteria

Question 10

Describe how the alternative pathway occurs

Answer 10

• C3B binds direct to antigen followed by C3B - C6 to C9
• C5B to C9 form Mac
• C3B exposed causing opsonization
• Convertase releases C3-5A which enhance chemotaxis

Question 11

What is mannose and what can bind to it in inflammation

Answer 11

• a certain sugar molecule which is receptor for some bacteria
• mannose binding lectin

Question 12

Explain lectin pathway

Answer 12

• MBL binds to mannose
• C4 binds next followed by C2 , C3B, C5B , C6 to C7
• C5B to C9 form Mac
• C3B exposed
• C3-5A break off