Inflammation/Autoimmune/Hypersensitivity Flashcards
What is important to know about acute inflammation?
PMNs within 24 hours
Fibrin
What about chronic inflammation
Mononuclear cells
Plasma, Lymph, Macro
What type of inflammation has granulation tissue?
Chronic
What happens to the DNA in a Lupus Patient?
Anti-DNA Ab form complexes with DNA that is released when cells turn over
What happens to the DNA-Ab complexes?
They circulate and lodge in small blood vessels
What happens after the CIC (Circulating Immune Complexes) lodge in the vessels?
Complement binds CIC and leads to tissue damage and WBC attraction
What organ is impacted heavily by Lupus
Kidney Glomeruli
What are some symptoms of Lupus?
Glomerulonephritis
Butterfly Rash
Acute Necrotizing Vasculitis
Skin Rashes
Rheumatoid Arthritis
Proliferative Synovitis
Ulnar Deviation
What is the problem with Spondyloarthropathies
Ligamentous attachments to bones are messed up
What gene is involved in Spondyloarthropathies
HLA-B27
What is affected the most by Sondylo
Sacroiliac Joints
Uvelitis
What is Sjogren’s Syndrome
Immune mediated destruction of lacrimal and salivary glands
What are symptoms of Sjogrens
Xerostomia
Keratoconjunctivits
What is Scleroderma
Inflammation/Fibrosis of the interstitium of organs
What are some symptoms of Scleroderma
CREST syndrom
Thick/ulcerated skin, hard time swallowing
Joint issues
Fibrotic lungs
What organ does the AI disease Hashimotos affect
Thyroid, Hypo
What organ does addison’s affect?
Adrenal glands, not enough cortisol
Fatigue, Depression, Abdominal Pain
What is Type I diabetes
AI destruction of beta cells
What is pernicious anemia?
AI disease where body can’t absorb B12
What is the Etiology of Most AI diseases?
Viral or bacteria infection triggers, or meds
What is the typical treatment for these diseases
Steroids
What are complications from long term steroid treatments?
Weight gain
Delayed wound healing
Accelerated Osteoporosis
