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Path Final Review > Inflammation/Autoimmune/Hypersensitivity > Flashcards

Inflammation/Autoimmune/Hypersensitivity Flashcards

1
Q

What is important to know about acute inflammation?

A

PMNs within 24 hours

Fibrin

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2
Q

What about chronic inflammation

A

Mononuclear cells

Plasma, Lymph, Macro

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3
Q

What type of inflammation has granulation tissue?

A

Chronic

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4
Q

What happens to the DNA in a Lupus Patient?

A

Anti-DNA Ab form complexes with DNA that is released when cells turn over

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5
Q

What happens to the DNA-Ab complexes?

A

They circulate and lodge in small blood vessels

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6
Q

What happens after the CIC (Circulating Immune Complexes) lodge in the vessels?

A

Complement binds CIC and leads to tissue damage and WBC attraction

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7
Q

What organ is impacted heavily by Lupus

A

Kidney Glomeruli

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8
Q

What are some symptoms of Lupus?

A

Glomerulonephritis
Butterfly Rash
Acute Necrotizing Vasculitis
Skin Rashes

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9
Q

Rheumatoid Arthritis

A

Proliferative Synovitis

Ulnar Deviation

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10
Q

What is the problem with Spondyloarthropathies

A

Ligamentous attachments to bones are messed up

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11
Q

What gene is involved in Spondyloarthropathies

A

HLA-B27

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12
Q

What is affected the most by Sondylo

A

Sacroiliac Joints

Uvelitis

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13
Q

What is Sjogren’s Syndrome

A

Immune mediated destruction of lacrimal and salivary glands

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14
Q

What are symptoms of Sjogrens

A

Xerostomia

Keratoconjunctivits

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15
Q

What is Scleroderma

A

Inflammation/Fibrosis of the interstitium of organs

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16
Q

What are some symptoms of Scleroderma

A

CREST syndrom
Thick/ulcerated skin, hard time swallowing
Joint issues
Fibrotic lungs

17
Q

What organ does the AI disease Hashimotos affect

A

Thyroid, Hypo

18
Q

What organ does addison’s affect?

A

Adrenal glands, not enough cortisol

Fatigue, Depression, Abdominal Pain

19
Q

What is Type I diabetes

A

AI destruction of beta cells

20
Q

What is pernicious anemia?

A

AI disease where body can’t absorb B12

21
Q

What is the Etiology of Most AI diseases?

A

Viral or bacteria infection triggers, or meds

22
Q

What is the typical treatment for these diseases

A

Steroids

23
Q

What are complications from long term steroid treatments?

A

Weight gain
Delayed wound healing
Accelerated Osteoporosis

Path Final Review (12 decks)

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