INFLAMMATION AND WOUND HEALING

Question 1

Inflammation is

Answer 1

the response of vascularized connective tissue to injury, characterized by extracellular fluid and leukocyte accumulation

Question 2

The main components of inflammation are – and –

Answer 2

a vascular reaction and a cellular response

Question 3

The steps of the inflammatory response can be remembered as the five Rs:

Answer 3

(1) recognition of the injurious agent,
(2) recruitment of leukocytes,
(3) removal of the agent,
(4) regulation (control) of the response, and
(5) resolution (repair).

Question 4

Types of inflammation

Answer 4

Acute, chronic and granulomatous

Question 5

In leukocyte recruitment loose attachment to and rolling on endothelium is mediated by

Answer 5

selectins

Question 6

In leukocyte recruitment firm attachment to endothelium is mediated by

Answer 6

integrins

Question 7

Transmigration of leukocytes is mediated by

Answer 7

CD31 (PECAM -1)

Question 8

The 4 most important mediators of acute inflammation are

Answer 8

vasoactive amines, lipid products (prostaglandins and leukotrienes), cytokines (including chemokines), and products of complement activation.

Question 9

T/F: Cell-derived mediators are normally sequestered in intracellular granules and can be rapidly secreted by granule exocytosis (e.g., histamine in mast cell granules) or are synthesized de novo (e.g., prostaglandins and leukotrienes, cytokines) in response to a stimulus.

Answer 9

T