Inflammation and Disorders of Growth Flashcards
Latin word that means to set fire
Inflammare
Universal response to tissue damage by wide range of harmful stimuli mechanical trauma, tissue necrosis and infection
Inflammation
Purpose of inflammation
- To destroy (or contain) the damaging agent
- To initiate repair processes
- To return the damaged tissue to useful function
Causes of inflammation:
- Living organisms
- Chemicals
- Mechanical and thermal injuries
- Immune reactions
Changes during inflammation:
- Blood vessel changes
- Changes in blood stream
- Changes in rate of flow
- Leukocytic emigration
- Diapedesis of RBCs
- Serum exudation
Changes of inflammation:
momentary contraction of the blood vessel
Blood vessel changes
vessels dilate causing more arterial blood
hyperemia
Changes of inflammation:
increased permeability of venules and capillaries
blood vessels changes
Changes of inflammation:
changes in erythrocyte distribution
Changes in blood stream
Mechanisms of leukocytes margination (pavement) is either:
a. WBCs gets adhesive
b. Capillary wall gets sticky (endothelium gets sticky)
Changes of inflammation:
Accelerate of the rate due to arteriolar dilation
Changes in rate of flow
Retardation of rate flow is due to:
- fluid loss leads to increased blood viscosity
- leukocyte stickiness
- stasis; exudation
Changes of inflammation:
ameboid movement of leukocytes towards the site of inflammation
leukocytic emigration
cause of leukocytic emigration
chemotractic forces
process of attraction of leukocytes to certain area that has the chemotactic substances
Chemotaxis
The action of neutrophils are
phagocytic
phagocytic power is shown toward
bacteria
large number of this are killed by bacterial toxins
neutrophils
production of pus
suppuration or purulent exudate
this produces pus
neutrophils
these cells present in the parasitic infection and hypersensitivity due to release of eosiniphils chemotactic factor from mast cells when intact with Ag+IgE to mast cells and release of histamine
Eosinophils
It is phagocytes cells inside the blood and when reach to the cells and tissue it will become macrophage cells or called histiocytes
monocytes
the function of this is to phagocytes foreign bodies
monocytes
they fuse to form multinucleated giant cells (langhan’s giant cell)
monocytes
it is similar to macrophage and similar to epithelial cells close to each other with no different borders between its cytoplasm and they tend to have small nucleus
Epithelioid cells
these cells are no phagocytic cells but release lysosomal enzyme
epithelioid cells
they form by fused the cytoplasm of the macrophages
giant cells
4 types of giant cells
- Langhan’s giant cell
- Foreign body giant cells
- Touton Giant cell
- Warthin-Finkeldy
Classification of inflammation according to time:
a. acute inflammation
b. subacute inflammation
c. chronic inflammation
inflammation extend from hours to few days: hyperemia and congestion, infiltration of PMN cells, and edema
Acute inflammation
inflammation that is extended from days to weeks –> macrophages and lymphocytes are found
Subacute inflammation
inflammation extended from weeks, months, years –> mononuclear cells
Chronic inflammation
Acute vs Chronic inflammation:
sudden onset
Acute inflammation
Acute vs Chronic inflammation:
last for weeks or months/years
Chronic inflammation
Acute vs Chronic inflammation:
vascular dilatation
Acute inflammation
Acute vs Chronic inflammation:
Predominantly mononuclear may also be present
Chronic inflammation
Acute vs Chronic inflammation:
increased vascular permeability
Acute inflammation
Acute vs Chronic inflammation:
neutrophil activation and migration
Acute inflammation
when this fails to subside within several weeks, this can lead to chronic inflammation
Acute inflammation
types of exudate:
- Serous inflammation (serous exudate)
- Fibrinous inflammation
- Purulent inflammation
- Hemorrhagic inflammation
- Catarrhal inflammation
It is characterized by increase exudation of the nuclear albuminous fluid which accumulates in the inflammation are showing the inflammatory edema
Serous inflammation
Microscopic app:
1- Watery fluid is seen in the cavity
2- Cloudy fluid and it have fibrin strands
3- Color could be red if there are RBC present
4- Hyperemic zone
Serous inflammation
Causes of serous inflammation:
1- Mechanical injury of tissue
2- Chemical –> chloroform
3- Biological –> virus FMD
4- Insects –> bee sting
characterized by too much fibrinogen clotting fibrin
Fibrinous inflammation
it is the inflammation characterized by pus formation
Purulent inflammation
is a liquid of creamy color and consistency but can be thin (watery) or (semi-solid). The color is blue green when caused by Pseudomonas aeruginosa
Pus
implies that large amounts of pus are produced
suppurative inflammation
is inflammation when there is good amount of pus diffusely scattered through a tissue especially the subcutis
phlegmonous inflammation
pyogenic bacteria that causes purulence:
- Stapylococci
- Stretococci
- E. coli
- Neisseriae
characterized by large numbers of RBCs that leave by diapedesis. the blood may exudes from body surface or nearby tissue
Hemorrhagic inflammation
Microscopic appearance:
large number of degenerate neutrophils are seen
Purulent inflammation
Gross appearance:
see blood-colored fluid or semi fluid usually clotted and gelatinous
hemorrhagic inflammation
is inflammation in which the exudate is mucus
catarrhal inflammation
it comes from the epithelial cells of mucous glands or form the giblet cells
mucus
inflammation of the mucous membranes
catarrhal inflammation
it can result in a thick exudate of mucus and white blood cells
catarrhal inflammation
caused by swelling of the mucous membranes in the head in response to an infection
catarrhal inflammation
5 cardinal signs of inflammation
Rubor - redness
Tumor - swelling
Calor - heat
Dolor - pain
Functio laessa - diminished function
due to arteriolar and capillary dilatation with increased rate of blood flow towards the site of injury
Rubor - redness
Due to increased capillary permeability causing extravasations of blood fluid
Tumor - swelling
due to transfer of internal heat to the surface or site of injury, brought about by increased blood content (hyperemia)
Calor - heat
due to pressure upon the sensory nerve by the exudates/tumor
Dolor - pain
destruction of the functioning units of the tissue
Functio laessa - diminished function
Inflammation of appendix
Appendicitis
Inflammation of fallopian tube
Slapingitis
Inflammation of pericardium
pericarditis
Inflammation of pleura
pluerisy
Inflammation of subcutaneous tissues
Cellulitis
Inflammation of meninges
meningitis
Inflammation of arteries
arteritis
Chronic inflammation subdivision:
- Non-specific chronic inflammation
- Specific (primary) chronic inflammation
- Granulomatous inflammation
arises following non-resolution of acute inflammation
Non-specific chronic inflammation
Arises de novo in response to certain types of injurious agents
Specific (primary) chronic inflammation
Subset of specific inflammation characterized by the presence of granulomas
Granulomatous inflammation