Inflammation Flashcards
what are the symptoms of inflammation
Rubor calor tumor dolor loos of function
why is rubor a symptom of inflammation
redness –> increased vascular leakage – build up of fluid and RBC
why is tumor a symptom of inflammation
swelling–> increased vascular leakage –> buildup of flui
why is calor a symptom of inflammation
increase metabolic activity of WBC
raising body temp prevents reproduction of viruses
why is dolor a symptom of inflammation
Prostaglandins hstamine + cytokines released by WBC act on nociceptor neurons
what are the causes of inflammation
non apototic cell death pathogens allergens cancer infection trauma
how does a damaged tissue differ to normal tissue
damage to epithelium and interstitium
intramuscular macrophages , DC exposed to antigen
leukocytes+ neutrophils migrate into cell from blood
what are the initial reactions to acute inflammation
DAMP and PAMPS detected in blood
vasodilators ( histamine + Nitrous oxides from mast cell+ cell soluable mediators )
changes in vasculature ( increase permeability, dilation )
recruitment of immune cells
name the cell soluble mediators
histamines prostaglandins cytokines chemokines complement
where are histamines produced and what is their role
basophils, mast cells , platelets
vasodilation
increase vascular permeability
endothelial activation
where are prostaglandins produced and what is their function
mast cells , leukocytes
vasodilation pain fever
where are cytokines produced and what is their function
macrophages, endothelial cells, mast cells
endothelial activation , fever, pain , malaise, shock
examples : TNF, Il1, IL7 –> activates chemokine synthesis cascade
where are chemokines produced and what is thier function
activated macro, leukocytes
chemotaxis of leukocytes
leukocyte activation
where are complement produced and what is their function
liver –> travels in plasma
opsonisation , vasodilation ( stimulates mast cells) , chemotaxis and activation of leukocytes
What is exudate
fluid , proteins and cells that have seeped out of the blood vessel
causes swelling
