Inflammation

Question 1

What is inflammation?

Answer 1

Complex reaction in viable vascularised tissue - protective mechanism to clear and deal with consequences of damaging molecule / event; many cells and mediators involved

Question 2

What is chronic inflammation?

Answer 2

Persistent response (weeks to years) - coexistence of ongoing damage and attempts to heal/rectify

Question 3

What are the 4 signs of inflammation?

Answer 3

Rubor
Calor (heat)
Tumor (swelling)
Dolor (pain)

Question 4

What are transudate substances?

Answer 4

Substances that normally exit vessels:
Ultrafiltrate
Low protein and cell content

Question 5

What are exudate substances?

Answer 5

Substances that leave circ during increased vascular permeability:
High protein and cell content
Cell debris
May be purulent (leukocyte rich)

Question 6

What is the purpose of exudate?

Answer 6

Dilutes and walls of pathogens to allow spread of solube inflammatory mediators

Question 7

What is Granulomatous inflammation?

Answer 7

Distinctive pattern of chronic inflammation showing granuloma formation - aggregate of activated macrophages that attempt to eliminate a resistant offending agent after T-cell trigger