Inflammation Flashcards
1
Q
What are the overall effects of glucocorticoids?
A
- Decreases migration of neutrophils
- Decreases activation of neutrophils and macrophages
- Decreases activation of T-lymphocytes and clonal expansion
- Deceased fibroblast activation, matrix deposition
- Decreases osteoblasts activation :. Bone not laid down
2
Q
What affects the duration of action of GCs?
A
- Fraction bound to plasma proteins
- Affinity for 11B-HSDII
- Lipophilicity
- Affinity for GCR
3
Q
What are some other side effects of GC?
A
- Glaucoma
- Adrenal crisis
- Immunosuppressive
4
Q
What is given for dermatological disorders?
A
- Hydrocortisone
2. Dexamethosone
5
Q
What are the side effects of NSAIDs?
A
- GI - peptic ulcers
- Renal effects
- Skin reactions
- All NSAIDs have CV problems :. Not given in USA —> give paracetamol instead
6
Q
What are the positive effects of NSAIDs?
A
- Anti-inflammatory
- Analgesic effects
- Anti-pyretic (less PGE)
7
Q
What is the mechanism of aspirin?
A
- Prostacyclin causes vasodilation and prevents platelet aggregation and vasoconstriction: produced by COX1 In vasculature
- Thromboxane A2 causes platelet aggregation and vasoconstriction - made by COX1 in platelets
- Aspirin inhibits COX irreversibly :. Only way to get more COX is by making more
- Platelet is anuclear :. Cannot do this :. No thromboxane
- Endothelial cells can make COX :. Balance shifts from thromboxane to prostacyclin :. No platelet aggregation
8
Q
What are the effects of TNF-alpha?
A
- Induce fever
- acute phase protein release
- Activates macrophages
- Promotes bone resorption by osteoclasts
- Promotes fibroblast proliferative
9
Q
Why is entercept fused with an antibody?
A
To prevent the receptor from being broken down in body
10
Q
What is infliximab?
A
Human F.C. region
Mouse Fv region
11
Q
What is CDP571?
A
- Humanised Ab against TNFa
12
Q
What is adalimumab?
A
Human Ab
