Inflammation Flashcards
Cells that release prostaglandin and histamine?
Mast cells, leukocytes, platelets
Exudate forms as a result of?
Increased permeability due to PG and histamine.
Attachment of wbcs to endothelium called
Marination
Adhesion molecules secreted by
Leukocytes and endothelial cells
Adhesion molecules
Selectins and integrins
Purpose of rouleau formation
Slows down blood flow so crucial events can take place
Serous exudate
Watery, few proteins, few cells
From mild acute inflammation
Purulent/Suppurative
Pus, leukocytes, necrotic debris
Cloudy foul odor (infection) from severe acute inflammation
Hemorrhagic
Large number erythrocytes, severe injury from severed vessels
Fibrinous
High amount fibrinogen & other components. Sticky mesh
Membranous
Development of mucous membrane. Necrotic cells in fibropurulent exudate
Local clinical signs of inflammation
Redness, pain, warmth, swelling, loss of function.
Systemic manifestations of inflammation
Malaise, fever, fatigue, headache
How fever effects infection
Enhances phagocytosis and immune response. Inhibits reproduction and growth of pathogens
Steps of vascular response
Vasoconstriction
Vasodilation
Increased permeability
Pathogenesis of fever
Exogenous pyrogens produced by microbes
Induce production of endogenous pyrogens by defense cells
Interlukins mediate production of PGE2
PGE2 travels to hypothalamus
Adjusts set point at hypothalamic receptor via cAMP
C Reactive Protein
Serum marker for inflammation
Produced by liver in response to inflammation
Has a role in defense via complement
Tx of Fever
App cold - vasoconstriction - dec. swelling
Elevation pressure - dec. bf - dec. exudate swelling
App heat - stimulates phagocytosis
NSAIDS in treating fever
Decrease prostaglandin synthesis to decrease pain
Steroidal anti inflammatory in treating fever
Decreases permeability, which decreases WBCS at site, which decreases pg and histamine release
