Inflammation

Question 1

Cells that release prostaglandin and histamine?

Answer 1

Mast cells, leukocytes, platelets

Question 2

Exudate forms as a result of?

Answer 2

Increased permeability due to PG and histamine.

Question 3

Attachment of wbcs to endothelium called

Answer 3

Marination

Question 4

Adhesion molecules secreted by

Answer 4

Leukocytes and endothelial cells

Question 5

Adhesion molecules

Answer 5

Selectins and integrins

Question 6

Purpose of rouleau formation

Answer 6

Slows down blood flow so crucial events can take place

Question 7

Serous exudate

Answer 7

Watery, few proteins, few cells

From mild acute inflammation

Question 8

Purulent/Suppurative

Answer 8

Pus, leukocytes, necrotic debris

Cloudy foul odor (infection) from severe acute inflammation

Question 9

Hemorrhagic

Answer 9

Large number erythrocytes, severe injury from severed vessels

Question 10

Fibrinous

Answer 10

High amount fibrinogen & other components. Sticky mesh

Question 11

Membranous

Answer 11

Development of mucous membrane. Necrotic cells in fibropurulent exudate

Question 12

Local clinical signs of inflammation

Answer 12

Redness, pain, warmth, swelling, loss of function.

Question 13

Systemic manifestations of inflammation

Answer 13

Malaise, fever, fatigue, headache

Question 14

How fever effects infection

Answer 14

Enhances phagocytosis and immune response. Inhibits reproduction and growth of pathogens

Question 15

Steps of vascular response

Answer 15

Vasoconstriction
Vasodilation
Increased permeability

Question 16

Pathogenesis of fever

Answer 16

Exogenous pyrogens produced by microbes

Induce production of endogenous pyrogens by defense cells

Interlukins mediate production of PGE2

PGE2 travels to hypothalamus

Adjusts set point at hypothalamic receptor via cAMP

Question 17

C Reactive Protein

Answer 17

Serum marker for inflammation
Produced by liver in response to inflammation
Has a role in defense via complement

Question 18

Tx of Fever

Answer 18

App cold - vasoconstriction - dec. swelling

Elevation pressure - dec. bf - dec. exudate swelling

App heat - stimulates phagocytosis

Question 19

NSAIDS in treating fever

Answer 19

Decrease prostaglandin synthesis to decrease pain

Question 20

Steroidal anti inflammatory in treating fever

Answer 20

Decreases permeability, which decreases WBCS at site, which decreases pg and histamine release