Abnormal immune Responses

Question 1

Immunodeficiency can be either

Answer 1

Primary or secondary

Question 2

Primary immunodeficiency is

Answer 2

Genetic or congenital due to a developmental failure

Question 3

Secondary immunodeficiency is

Answer 3

Acquired, post natal. Due to immunosuppressive drugs, cancer treatment, or an infection

Question 4

5 types immunodeficiency

Answer 4

T cell disorders 
B cell disorders 
T&B cell disorders 
Complement disorders 
Disorders of phagocytosis

Question 5

Tx for immunodeficiency

Answer 5

Replacement therapy (gamma globulin injections) or marrow/transplant

Question 6

Hypersensitivity is

Answer 6

IR exaggerated or inappropriate leading to tissue damage

Question 7

Immunodeficiency is

Answer 7

Partial or complete loss of IR

Increased risk of disease

Question 8

Type 1 HS

Answer 8

IgE mediated

Ag - helper t - B cell stim - IgE abs secreted - attach to mast cell

Ag binds to ab on MC - triggers MC to release mediators- inflm- tissue damage

Question 9

Type 2 HS

Answer 9

IgM and IgG bind to AGs on self cell surfaces (mistargeted) then destroyed by complement, phagocytosis and inflm

Question 10

Type 3 HS

Answer 10

IC of ag+ab not broken down d/t insolubility or small size

Circulates in blood- deposits on edothelium- defense cells destroy complex and endothelium with it - increase pore size, tissue injury, inflammation

Question 11

Type 4 HS

Answer 11

APC - h T cell - T cell sensitization- creation cytotoxic T cells- destroy APC - iflm - tissue damage

Can be
Direct destruction of apcs
Delayed d/t T cells producing lymphokines to destroy apcs takes time