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BOD > Inflammation > Flashcards

Inflammation Flashcards

1
Q

Platelet: Dense Granules

A 
TXA2
ADP
Calcium
Histamine
5HT
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2
Q

Platelet: Alpha Granules

A 
Fibrinogen
Factor 5 + 7
TGF-beta
PDGF
P selectin
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3
Q

Mast Cells

A

5-HT, Histamine
Prostaglandins, Leukotrienes
TNF-Alpha

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4
Q

Endothelia: Intact

A

Antithrombin
Thrombomodulin
PGI2
TFPI (= Tissue Factor Pathway Inhibitor)

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5
Q

Endothelia: Broken

A 
Thromboplastin
Von Willebrand Factor
PECAM1
ICAM1
E/P Selectin
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6
Q

Macrophages

A

Acute Cytokines: IL-1, TNFa, IL-6
Chronic: IL-12
Chemokine: CXCL8 (nø attractant)

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7
Q

TNF alpha and IL 1

A

Systemic: Fever, leukocytosis, acute phase response (liver, CRP and MRP), reduce appetite, promote sleep
Local:
1) Vascular - upregulate endothelial adhesin expression, procoagulant
2) Leukocytes - Activation, cytokine release
3) Fibroblasts - Replication, collagen production

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8
Q

IL-6

A

Acute phase response

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9
Q

IL-17

A

Chronic inflammation.
From Tø.
Increases nø and mø recruitment

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10
Q

IL-12

A

Chronic Inflammation.
From mø
Activates IFNy release -> Macrophage activation

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BOD (5 decks)

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