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BOD > Immunity > Flashcards

Immunity Flashcards

1
Q

CD28

A

T cell coreceptor

Binds B7 on APCS

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2
Q

CD40L

A

T cell coreceptor

Binds CD40 on APCs

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3
Q

After receiving Signal 1 + Signal 2, T cells release

A

IL-12 -> amplification

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4
Q

Signal 1 for B cell activation

A

Antigen endocytosis -> MHC II expression -> TCR binding

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5
Q

Signal 2 for B cell activation

A

Costimulation Binding (CD40 cross linking)

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6
Q

Light Chain Immunoglobulin

A

One constant

One variable domain (kappa or lambda)

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7
Q

Heavy Chain Immunoglobulin

A

One variable
Three (IgG/A/D) or Four (IgE/M) Constant domains
Distinguished by alpha/delta/epsilon/gamma/mew

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8
Q

Most variable region & why

A

CDR3 - due to VDJ junctional diversity and somatic hypermutation during affinity maturation (Activation induced Deaminase (AID) -> cytosine replaced by uracil)

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9
Q

Initial immunoglobin types formed

A

IgM and IgD - generated by alternate splicing

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10
Q

FCgRI

A

High affinity for IgG, found on mø and nø

Phagocytosis

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11
Q

FCgRIIa

A

Low affinity for IgG
mø and nø
Phagocytosis

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12
Q

FCgRIIb

A

Low affinity
Bø
Antibody regulation

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13
Q

FCgRIIIa

A

Low affinity
NK, mø
ADCC -> granule & perforin release

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14
Q

FCgRIIIb

A

Low affinity
nø
Phagocytosis

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15
Q

MHC Class I

A

HLA A, B, C alleles
8-9 aa peptide
Expresses endogenous proteins via proteosome, TAP1 & 2.

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16
Q

MHC Class II

A

HLA DP, DQ, DR
13-25aa peptide -> open ended
Binds exogenous peptides via endosomes and ER. Invariant chain acts as chaperone.

17
Q

Hypersensitivity Type I

A

Acute
IgE/Mast cell mediated
Anaphylotoxins (complement, etc)
eg. Pollen/nut allergies

18
Q

Hypersensitivity Type II

A

Antibody mediated

eg. Haemolytic disease of the newborn/blood transfusions

19
Q

Hypersensitivity Type III

A

Immune Complex Mediated

eg. Glomeronephritis (streptococcus), Lyme disease, lupus

20
Q

Hypersensitivity Type IV

A

Delayed type
T cell mediated
eg. contact dermatitis, tuberculosis

BOD (5 decks)

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