Inflammation

Question 1

Steps in leukocyte extravasation

Answer 1

1. Induction of adhesion molecules on the leukocyte by mediators (IL1, etc)
2. Expression of E selectin on endothelial cells
3. Diapedesis

Question 2

Diapedesis

Answer 2

Secretion of collagenase by the leukocytes help them to pierce the basement membrane and accumulate at the site of injury.

Question 3

Chemo taxis

Answer 3

It is mediated by chemoattractants, which may be endogenous or exogenous

Question 4

Endogenous chemoattractants

Answer 4

C5a, LTB4, IL-8 etc

Question 5

Exogenous chemoattractants

Answer 5

Bacterial endotoxins

Question 6

Chemoattractants bind to

Answer 6

G protein - coupled receptors

Question 7

Calls going to do phagocytosis must recognise and attach to the invading agent via

Answer 7

1. Mannose receptors and
2. Scavenger receptors

Question 8

Phagocytosis

Answer 8

1. Oxygen dependent mechanism
2. Oxygen independent mechanism

Question 9

Acute phas3 reactants

Answer 9

1. C reactive protein
   2.fibrinogen
2. Serum Amyloid A protein

Question 10

Synthesis of acute phase reactants is controlled by

Answer 10

IL6
IL1
TNF

Question 11

Types of acute Inflammation

Answer 11

1. Serous
2. Fibrinous
3. Hemorrhagic
4. Suppurative
5. Pseudomembranous