Inflammation Flashcards
What needs to happen for the inflammatory response to happen?
Vascular response ( increased blood flow to the site of injury), cellular response (alert healing products to come to the site of injury), and removing the injured tissue to prepare for healing
Why is the inflammatory response so important in healing?
Getting blood to the site of injury allows cells that participate in phagocytosis to come to the area. It also allows platelets to come to the area and clot
Cellular inflammatory mediators
White blood cells, platelets, and endothelial tissues
Inflammatory mediators in plasma
Kinin system, complement system, clotting system
Cellular response
Involves chemotaxis, cellular adherence, and cellular migration
Local signs of inflammation
Redness, heat, incapacitation, edema, and pain
Acute vs chronic inflammation
Acute: resolves within a few weeks, Neutrophils are the chief cells, and results in minimal scarring
Chronic: lasts more than 6 months, chief cells are Lymphocytes, Monocytes, and Macrophages, and usually results in some scarring
Three phases of wound healing
Inflammatory (seals the wound), proliferative (cleans the debris and restores structural integrity), Remodeling (structural integrity and remodeling)