Inflammatio 2

Question 1

how do neutrophils kill what they phagocytose?

Answer 1

form activated oxygen molecules. enzymatic mechanisms (lysosomes/proteases)

Question 2

3 most important protein and polypeptide mediators of acute inflammatory response

Answer 2

bradykinin. C3a and C5a (complement factors). thrombin.

Question 3

chronic inflammation occurs in 3 specific situations

Answer 3

persistent stimulus. persistent autoimmune diseases. viral infections.

Question 4

4 ways chronic inflammation is different from acute

Answer 4

longer to develop (days/months vs. minutes/hours). more likely to involve specific recognition. cell infiltrate mostly lymphocytes and mononuclear phagocytes. more likely to be a permanent change in tissue arhitecture

Question 5

most important players in chronic inflammation

Answer 5

mononuclear phagocytes: derived from bone marrow monocytes –> then called macrophages when mature

Question 6

3 ways mononuclear phagocytes are different from neutrophils

Answer 6

longer life span in tissue. improtant sources of cytokines. can present antigen to MHC Class II restricted cells like CD4 helper T cells

Question 7

granuloma

Answer 7

localized collection of mononuclear phagocytes

Question 8

granuloma: what do they look like?

Answer 8

visible in tissue sections as balls of pink-staining cells which have a lot of cytoplasm

Question 9

chronic inflammation is usually accompanied by

Answer 9

tissue repair activity: new blood vessel growth, fibrosis aka scarring