Inflammatio 2 Flashcards

1
Q

how do neutrophils kill what they phagocytose?

A

form activated oxygen molecules. enzymatic mechanisms (lysosomes/proteases)

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2
Q

3 most important protein and polypeptide mediators of acute inflammatory response

A

bradykinin. C3a and C5a (complement factors). thrombin.

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3
Q

chronic inflammation occurs in 3 specific situations

A

persistent stimulus. persistent autoimmune diseases. viral infections.

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4
Q

4 ways chronic inflammation is different from acute

A

longer to develop (days/months vs. minutes/hours). more likely to involve specific recognition. cell infiltrate mostly lymphocytes and mononuclear phagocytes. more likely to be a permanent change in tissue arhitecture

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5
Q

most important players in chronic inflammation

A

mononuclear phagocytes: derived from bone marrow monocytes –> then called macrophages when mature

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6
Q

3 ways mononuclear phagocytes are different from neutrophils

A

longer life span in tissue. improtant sources of cytokines. can present antigen to MHC Class II restricted cells like CD4 helper T cells

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7
Q

granuloma

A

localized collection of mononuclear phagocytes

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8
Q

granuloma: what do they look like?

A

visible in tissue sections as balls of pink-staining cells which have a lot of cytoplasm

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9
Q

chronic inflammation is usually accompanied by

A

tissue repair activity: new blood vessel growth, fibrosis aka scarring

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