infertility Flashcards

1
Q

how many couples are affected by infertility

A

1 in 6

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2
Q

what is the definition of infertility

A

failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sex in a couple who have never conceived a child

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3
Q

what is the role of sertoli cells

A

secrete seminiferous fluid, androgen binding globulin , inhibin and activin hormones
create blood testes barrier
provide nutrients
destroy defective sperm
remove excess cytoplasm from seminiferous tubules

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4
Q

what is the role of androgen binding globulin

A

for sperm production - binds testosterone

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5
Q

role of inhibin and activin

A

regulation of FSH secretion adn control of spermatogenesis

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6
Q

where does spermatogenesis occur

A

inside seminferous tubules

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7
Q

where are sperm stored

A

epidydmis

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8
Q

what does seminal vesicle do

A

releases fluid containing
fructose
pg’s (make vag contract)
fibrinogens

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9
Q

how often is GnRh released from hypothalamus

A

every 2-3 hrs not cyclical like females

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10
Q

what does Lh stimulate in males

A

testosterone release from leydig cells

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11
Q

surges of what hormones stimulate spermatogenesis

A

testosterone and FSH

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12
Q

give examples of obstructive male inferitility and endocrine features expected

A

CF - no vas deferens

norm LH, FSH and testosterone

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13
Q

when do the make testes usually descend

A

6-9 months

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14
Q

what does globozoospermia mean

A

sperm have rounded head and no acrosome

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15
Q

what would endocrine features of non-obstructive infertility be

A

high LH and FSH low testosterone

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16
Q

in anovulatory infertility in women if the cause is due to the hypothalamus eg anorexia nervosa what endocrine features are expected ?

A

low FSH, LH and oestradiol

17
Q

in POF what endocrine features are expected

A

HIGH LH and FSH and low oestradiol (ovaries stopped producing oestrogen )