Infertility

Question 1

RPL

Answer 1

• two or more failed clinical pregnancies as documented per ultrasound or histopatholigical exam
• three consecutive pregnancy losses (do not have to be IUPs)

Question 2

uterine factors

Answer 2

• acquired and congenital abnormalities are responsible for 10-50% of RPL
• can depend on population
• requires further examination/investigation

Question 3

endocrine causes of RPL

Answer 3

• diabetes
• thyroid abnormalities
• luteal phase defects and low progesterone
• PCOS

Question 4

immunological causes of RPL

Answer 4

• antiphospholipid antibody syndrome

- blood group alloimmunization

Question 5

genetic causes of RPL

Answer 5

• aneuploidy
• chromosomal rearrangements
• inherited thrombophilias

Question 6

chromosomal difference incidence in RPL couples

Answer 6

-4% have this (versus 0.7% of the general population)
+40% with Robs
+60% with reciprocal

Question 7

environmental causes of RPL

Answer 7

• chemical agents (benzene, formaldehyde)
• smoking
• illicit substance use
• infection