Infective Endocarditis

Question 1

Tx for native valve streptococcal infection

Answer 1

Penicillin G (or ceftriaxone)

Question 2

Tx for native valve staphylococcal infection

Answer 2

Naficillin (or oxacillin)

Question 3

Why is gentamicin added to the infective endocarditis regimen

Answer 3

to shorten course of treatment (can only use gentamicin for 2 weeks before you need to be concerned for toxicities)

Question 4

Tx for infective endocarditis caused by enterococci

Answer 4

Ampicillin

Question 5

Tx for HACEK microorganisms infective endocarditis

Answer 5

Ceftriaxone (or Ampicillin)

Question 6

Which beta lactam antibiotic is best for streptococcal infection

Answer 6

Penicillin (or ceftriaxone)

Question 7

Which beta lactam antibiotic is best for staphylococcal infection?

Answer 7

Nafcillin (or oxacillin)

Question 8

Which beta lactam antibiotic is best for enterococcal or HACEK organisms?

Answer 8

Ampicillin

Question 9

What Tx would you recommend for a prosthetic valve endocarditis with oxacillin-susceptible staphylococci?

Answer 9

1. Nafcillin (or oxacillin)
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Rifampin
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Gentamicin

Question 10

What Tx would you recommend for a prosthetic valve endocarditis with oxacillin-susceptible staphylococci?

Answer 10

Nafcillin (or oxacillin)
\+
Rifampin
\+
Gentamicin

Question 11

What Tx would you give to a patient with prosthetic valve endocarditis with oxacillin-resistant staphylococci?

Answer 11

Vancomycin
\+
Rifampin
\+
Gentamicin

Question 12

What is the treatment for infective endocarditis prophylaxis?

Answer 12

Amoxicillin 2g (or clindamycin 600mg) 30min to 60min before proceedure