HIV overview

Question 1

What is a good website for AIDs info

Answer 1

aidsinfo.nih.gov

Question 2

Initial treatment of HIV: concept

Answer 2

minimum of 3 active antiretroviral agents from at least 2 drug classes

Question 3

First line HIV regimen

Answer 3

2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) + INSTI (or NNRTI or PI) + cobicistat

Question 4

What does cobicistat

(Tybost) do?

Answer 4

boosts effectiveness of the PI (protease inhibitor)

Question 5

Common ADEs for HIV drugs: long term

Answer 5

1. lipodystrophy (problem with how body makes and stores fat)
2. Hyperlipidemia
3. Osteoporosis

Question 6

Short term ADEs with HIV medications

Answer 6

fatigue
N/V/D
Headache
Fever
Muscle pain
Dizziness

Question 7

What is the main pathogen <200 CD4

Answer 7

Pneumocystic jirovecii

Tx: TMP-SMX

Question 8

What is the main pathogen for CD4 <100?

Answer 8

Toxoplasmosis

Tx: TMP-SMX

Question 9

What is the main pathogen for CD4 <50

Answer 9

Mycobacterium avium

Tx: Azithromycin 1200mg weekly

Question 10

Which antiretroviral agents are recommended in pregnancy?

Answer 10

1. Nucleoside reverse transcriptase inhibitors (NRTIs)
2. Nonnucleoside reverse transcriptase inhibitors (NNRTIs)
3. Protease inhibitors (PIs)

Question 11

Which vaccines need to be avoided in HIV

Answer 11

1. MMR
2. Varicella
3. Herpes Zoster