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MedED Year 3 - Infectious Diseases > Infectious Mononucleosis > Flashcards

Infectious Mononucleosis Flashcards

1
Q

Causative organism of infectious mono

A

EBV (Epstein-Barr Virus)

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2
Q

% people affected at some point in their life by infectious mono

A

90-95%

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3
Q

Method of transmission of EBV in infectious mono

A

Saliva/respiratory droplets (‘kissing disease’)

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4
Q

Infectious mono aetiology

A

EBV incorporates viral DNA into host DNA in B lymphocytes causing atypical lymphocytosis

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5
Q

Presentation of infectious mono

A

Fever
Hepatosplenomegaly (jaundice)
Pharyngitis (tonsillar exudates)
Lymphadenopathy (posterior cervical nodes)

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6
Q

Investigations in infectious mononucleosis

A
  • FBC (lymphocytosis, highest in week 2-3)
  • Blood film (atypical lymphocytosis)
  • Heterophile antibodies (monospot test)
  • EBV-specific antibodies
  • Real time PCR-EBV DNA detection
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7
Q

Investigation to exclude Group A strep (strep pyogenes)

A

Throat swab

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8
Q

Management of infectious mono

A

Supportive - paracetamol or ibuprofen

Corticosteroids if severe (haemolytic anaemia/tonsillar swelling/obstructive pharyngitis)

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9
Q

ABx to avoid in infectious mono

A

Amoxicillin or ampicillin (contraindicated due to widespread maculopapular rash)

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10
Q

Prognosis of infectious mono

A

Most make an uncomplicated recovery in 3-21 days

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11
Q

3 components of EBV specific antibody test

A

EBV viral capsid antigens
1 - VCA IgM
2 - VCA IgG
3 - Epstein-Barr nuclear antigen (EBNA) (appears 6-12 weeks after symptoms)

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12
Q

EBV-specific antibody test result:
VCA IgM - negative
VCA IgG - negative
EBNA IgG - negative

Interpretation?

A

Negative EBV status

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13
Q

EBV-specific antibody test result:
VCA IgM - positive
VCA IgG - negative
EBNA IgG - negative

Interpretation?

A

Early primary infection

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14
Q

EBV-specific antibody test result:
VCA IgM - positive
VCA IgG - positive
EBNA IgG - negative

Interpretation?

A

Acute primary infection

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15
Q

EBV-specific antibody test result:
VCA IgM - negative
VCA IgG - positive
EBNA IgG - positive

Interpretation?

A

Past infection

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16
Q

Way of remembering IgM/G status of infectious mono

A

IgG - Gone

IgM - Now

MedED Year 3 - Infectious Diseases (13 decks)

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