Herpes Simplex Virus Flashcards
1
Q
Commonness of HSV1?
A
Very - 90% adults seropositive for HSV1 by 30 years
2
Q
Gingivostomatitis, cold sores (herpes labialis) Herpetic whitlow Eczema herpeticum Herpes simplex meningitis, encephalitis Systemic infection Keratoconjunctivitis - presentation of?
A
HSV 1
- more skin/CNS-related + herpes labialis
3
Q
Genital herpes (chronic, life-long) - flu-like prodrome - vesicles/papules around genitals/anus Shallow ulcers Urethral discharge Dysuria Fever and malaise - presentation of?
A
HSV 2
- more genital/discharge-related
4
Q
Aetiology of HSV?
A
Virus becomes dormant following primary infection?
5
Q
Site of HSV dormancy?
A
Trigeminal/sacral root ganglia
6
Q
Stimulus for HSV reactivation?
A
Stress
Immunosuppression (HIV)
7
Q
HSV latent phase
A
Chronic infection where infectious virions are not produced
- asymptomatic
8
Q
HSV lytic phase
A
Viral replication and transport of virus to skin
- active infection
9
Q
HSV investigations
A
Usually clinical diagnosis
- viral culture
- HSV PCR
10
Q
HSV management
A
Topical/oral/IV acyclovir
