Infectious diseases Flashcards
Clostridium botulinum types __ and __ affect birds; type ___ affects humans
C and E
E
What is the effective brucella vaccine for wild cervids
There is no effective vaccine
At what age should wild cervids begin testing for CWD
12 months of age
Which federal agency has jurisdiction over game meat and farmed cervids
FDA
Avian cholera is caused by ____; which is often introduced to poultry by ____.
pasturella; rodents
_____ is the primary test for TB in cattle; _____ is the primary test for TB in captive cervids
Caudal fold
Single Cervical
Contagious Equine Metritis (CEM) causes _(clinical signs)__ in mares and __(clinical signs)___ in stallions
Short-term infertility and vulvar discharge
No clinical signs; acts as a commensal bacteria
Causal agent of CEM
Taylorella equigenitalis
Modes of transmission for CEM
1) direct or indirect venereal contact
2) transplacental or contact with birth tissues
3) Fomites
How to test for CEM in carrier mares? In stallions?
1) Swab clitoral sinuses/fossa (can be intermittent shedders)- some positives are serologically negative
2) Ideal is to breed to two mares then test them; less ideal swab penis/urethra (culture/cytology)- males always seronegative
Causative agent Equine Piroplasmosis
Babesia (Theileria) equi
Babesia caballi
Equine piroplasmosis transmitted by ____
Ticks (Dermacentor variabilis and Boophilus microplus)
Shared blood/needles
The reservoir species for Babesia (Theileria) equi is ____; the reserveroir species for Babesia caballi is ____
Horses;
Horses and ticks (transovarial transmission)
Best ways to prevent equine piroplasmosis (3)
- Acaricides (needs tick vector)
- Need adequate number of infected horses in an area to support disease transmission
- Don’t reuse needles/blood products
Clinical signs equine piroplasmosis
Anemia, fever, jaundice, dark urine, lethargy, exercise intolerance (mild to severe)
What is the risk for food poisoning from MRSA strains?
Low/none; they aren’t enterotoxin producing staph aureus strains
What are the ten steps of an outbreak investigation
- Determine the existence of the outbreak
- Confirm the diagnosis
- Define a case and count cases
- Orient the data in terms of time, place, and person
- Determine who is at risk of becoming ill
- Develop a hypothesis that explains the exposure that caused disease and test this hypothesis
- Compare the hypothesis with the established facts
- Plan a more systematic study
- Prepare a written report
- Execute control and prevention measures
CWD transmissision routes?
Feces, urine, saliva
Offical tests for CWD herd surveillance?
(gold standard) Immunohistochemistry of obex or retropharyngeal LNs
or
Rapid ELISA of obex or retropharyngeal LNs
Within the CFR, standards can be written as “design standards” or “performance standards”. What is the difference?
Design standards are very specific and require rulemaking to change, eg “ramps must be 36 inches wide and no more than 15 degree slope” (how-to is within CFR)
Performance standards are more vague in execution allowing flexibility over time, eg “ramps must be of sufficient size to allow free passage by livestock without touching any side” (how-to is in guidance documents)
Primary mode of transmission for : Brucella abortis B. mellitensis B. suis B. canis
- Ingestion/tonsils/retropharyngeal LNs
- sexual
- sexual
- sexual
Reservoir species for brucella in USA?
Feral swine
Elk/Bison in Greater Yellowstone area
Human modes of infection with brucella in US?
Hunting feral swine, illegally imported dairy products, less often contact with aborted tissues, foreign exposures
Birds have ___ type receptors for influenza viruses
Humans have ___ type receptors
Swine have ___ type receptors
Birds= 2, 3'-sialyllactose Humans = 2, 6'-sialyl N-acetyllactosamine Swine = both α-2, 3 and α-2, 6 sialic acid receptor sites (that's why they're mixing pots)
three conditions for a global influenza pandemic
- A new subtype of influenza A virus is introduced into
the human population. - Virus causes serious disease in humans
- The virus can spread easily from person-to-person
in a sustained manner.
Appropriate manners to decontaminate prion properties (such as CWD)?
Physical: Irradiation, dry heat, autoclave
Chemical: currently no EPA-approved but some may work
Infected carcass: only alkaline hydrolysis inactivates completely
Equine Herpesvirus Myeloencephalopathy (EHM) is caused by ____
Equine HerpesVirus-1 (but not all EHV-1 causes the neuro form)
Primary forms of EHV in horses are __ and ___
EHV-1 and EHV-4
Modes of transmission for EHV in horses?
Inhalation, contact with aborted tissues
Vaccines against EHV protect against __ form(s) of disease but not ___ form(s)
Protect against respiratory and abortion signs but not neuro signs
Vaccinate livestock against anthrax using _____; vaccinate people using ______
Modified live (Sterne's) Cell-free filtrate
How to diagnose anthrax?
Culture lesions, blood,
How to tx anthrax?
Cipro, doxycycline, penicillin
Common name for brucellosis?
Undulent fever
Common name for botulisum in birds?
Limber neck
Three forms of human plague
Bubonic, pneumonic, septicemic
Oral rabies bait exists for which wildlife species in US?
Raccoon, fox
Vector species for tularemia?
Ticks (Dermacentor, Amblyomma)
Flies (Deer fly)
Three forms of human tularemia
Ulceroglandular, Typhoidal, Pneumonic (less likely ocular in children)
Prevention strategies for tularemia (4)
Insect repellent
PPE for skinning wildlife
Cook game meat thoroughly
Avoid contaminated drinking/swimming water
Vectors for WNV?
Mosquitoes: Culex pipiens (night feeder), Aedes aegypti (day feeder)
Ticks: Argasid (soft), amblyommine (hard)
Flies: Hippoboscid flies (flat flies)
Trichinella larvae in meat can be killed by __ or __ but not ___ or ___
Cooking or freezing
Salting or curing
Testing for hantavirus in human cases is ____ or ____; or if deceased ____
IgM +/- IgG (most commonly) or PCR
IHC if deceased
Transmission of Schmallenberg virus is via____
Culicoides midges; maternal-fetal, infected aborted tissues, also isolated in bovine semen (experimental)
Clinical signs Schmallenberg in cattle is ____. Sheep/goats is ______.
cattle: fever, reduced milk yield, teratogenic abortions;
sheep/goats- minimal signs in adults, arthrogryposis
and hydranencephaly syndrome (AHS) in fetus/lamb/kid
Prevention strategy for Schmallenberg virus
Alter breeding schedule so that pregnancy doesn’t coincide with culicoides activity
Chagas caused by ___ with ___ vector
Trypanosoma cruzi; Triatomine bug vector (Reduviidae)
Host species for Chagas
Opossums, skunks, raccoons, coyotes rodents
Disease in humans and dogs
Route of transmission for Chagas
- Wound contamination by bug feces
- Ingestion of infected vector (eg dogs eat bugs) or infected wild mammal
- Ingestion of contaminated food or drink (eg fruit juices with bug feces in it)
- Congenital (mother to offspring)
- Blood-borne (most NA blood banks screen for T.cruzi)
- Trans-mammary
- Organ transplant
Diagnosis of Chagas in canines
IFA is gold standard (Ab detection); histopath of heart or ID of parasite on blood smear.
Some PCR available
Lone star tick = (species)
Amblyomma americanum
Deer tick = (common name, species)
Black legged tick aka Ixodes scapularis
Brown dog tick = (common name, species)
Wood tick; Dermacentor variabilis
Four zoonoses associated with black legged tick/deer tick/Ixodes scapularis
Lyme disease (Borrelia burgdorferi), Powassan disease virus, Anaplasmosis (Anaplasma phagocytophilum), Babesiosis (Babesia microti)
Most Lyme transmission comes from ___ tick stage
Nymph stage. No transovarial transmission, so larvae stage not infected; adults are more likely to be spotted and removed.
Three lone star tick (Amblyomma americanum) zoonoses:
Ehrlichiosis, STARI (Southern tick associated rash illness- ethiology unknown), Heartland virus
Main reservoir species for Ehrlichiosis all stages
White tail deer (less often dogs, coyotes, goats, raccoons)
Cytologic ID of Ehrlichia by ___
Morulae in neutrophils on blood smear
In human cases of WNV, __% have no symptoms; ___% have west nile fever, and __% have West Nile neuroinvasive disease (WNND)
80% asymptomatic
20% fever
< 1% meningitis, encephalitis
WNV fatality rate in horses?
30-40% (neuro signs, ataxia, circling, etc)
Symptoms of EEE and case fatality rate in horses?
over 90% fatal; early fever, anorexia progress to neuro signs
The incidence of WNV tends to affect the _____ ages while EEE tends to affect the ____ ages
WNV- elderly;
EEE- very young and very old
After issuing a Veterinary Feed Directive, the vet must keep record of forms for ___ (time)___
2 years
Dengue virus immunity is ____
lifelong to specific subtype infected with only
Vector for dengue and Chikungunya virus
Aedes aegypti and albopictus
Common name for anthrax?
Wool sorter’s disease
Robert Koch used ____ bacteria to prove Koch’s postulates
Bacillus anthracis
Historically, Leptospira serovars ___ and ___ were most important in canine species, but now serovars ____ are emerging
Historical: L. canicola and L. icterohemorrhagiae
Emerging: L. pomona, L. grippotyphosa, L. autumnalis, L. bratislava
Lepto transmisssion routes
Contact with infected water, soil, urine, feces through abraded skin or mucous membranes,
direct ingestion, transplacental, bite wounds, venereal
Generally each lepto serovar has maintainence host species that (does/does not) cause illness in that species
Usually asymptomatic however can become ill
Reservoir species for L. icterohemorrhagiae
rat
Reservoir species for L. canicola
Dog
Reservoir species for L. pomona
Cow, swine, skunk, possum
Reservoir species for L. grippotyphosa
Vole, raccoon, skunk, opossum