∏-Infectious Diseases 1 Flashcards
define recrudescence
a repeated attack of malaria due to the survival of malaria parasites in RBCs (CDC)
define relapse
recurrense of disease after it has been apparently cured. in Malaria, true relapses are caused by reactivation of HYPNOZOITES (CDC)
Thick vs thin smears
thick - screens for presence
thin - species identification
highest yield of thick and thin smears
blood sample taken during fever or 2-3 hours after peak
septic shock in malaria
algid malaria
areas of chloroquuine-resistance in malaria
palawan
davao del norte
compostela valley
DOC for severe lepto
ceftriaxone?
s/e of methicillin
interstitial nephritis
cefamandole, what generation
2nd
DOC for penicillin-allergic patients
erythromycin
tx for drug-resistant ggonorrhea
spectinomycin
aminoglycoside with widest spectrum of activity
amikacin
can aminoglycosides kill anaerobes?
no
4th gen quinolone
gatifloxacin?
s/e: diabetes
most active drug vs M leprae
DAPSONE
- moa: inhibits folate synthesis
- s/e: methemoglobinemia
MOA of clofazimine
MOA: phenazine dye; binds to guanine bases
s/e: skin discoloration
most efficacious antifungal drug
amphotericin B
s/e of acyclovir
crystalluria
binds gp41 subunit
enfuvirtide
fusion inhibitor
CCR5 antagonist
Maraviroc
binding inhibitor
primary drug for malaria
chloroquine
-prevents heme polymerization into hemozoin
DOC for pregnant patients with malaria
quinine 📌
-s/e: hypoglycemia, cinchonism
chemoprophylaxis for multi-drug resistant areas (malaria)
doxycycline
chemoprophylaxis for chloroquine-resistant areas (malaria
mefloquine, malarone
