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IM; Re 4 > ∏-Infectious Diseases 1 > Flashcards

∏-Infectious Diseases 1 Flashcards

1
Q

define recrudescence

A

a repeated attack of malaria due to the survival of malaria parasites in RBCs (CDC)

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2
Q

define relapse

A

recurrense of disease after it has been apparently cured. in Malaria, true relapses are caused by reactivation of HYPNOZOITES (CDC)

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3
Q

Thick vs thin smears

A

thick - screens for presence

thin - species identification

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4
Q

highest yield of thick and thin smears

A

blood sample taken during fever or 2-3 hours after peak

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5
Q

septic shock in malaria

A

algid malaria

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6
Q

areas of chloroquuine-resistance in malaria

A

palawan
davao del norte
compostela valley

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7
Q

DOC for severe lepto

A

ceftriaxone?

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8
Q

s/e of methicillin

A

interstitial nephritis

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9
Q

cefamandole, what generation

A

2nd

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10
Q

DOC for penicillin-allergic patients

A

erythromycin

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11
Q

tx for drug-resistant ggonorrhea

A

spectinomycin

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12
Q

aminoglycoside with widest spectrum of activity

A

amikacin

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13
Q

can aminoglycosides kill anaerobes?

A

no

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14
Q

4th gen quinolone

A

gatifloxacin?

s/e: diabetes

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15
Q

most active drug vs M leprae

A

DAPSONE

  • moa: inhibits folate synthesis
  • s/e: methemoglobinemia
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16
Q

MOA of clofazimine

A

MOA: phenazine dye; binds to guanine bases

s/e: skin discoloration

17
Q

most efficacious antifungal drug

A

amphotericin B

18
Q

s/e of acyclovir

A

crystalluria

19
Q

binds gp41 subunit

A

enfuvirtide

fusion inhibitor

20
Q

CCR5 antagonist

A

Maraviroc

binding inhibitor

21
Q

primary drug for malaria

A

chloroquine

-prevents heme polymerization into hemozoin

22
Q

DOC for pregnant patients with malaria

A

quinine 📌

-s/e: hypoglycemia, cinchonism

23
Q

chemoprophylaxis for multi-drug resistant areas (malaria)

A

doxycycline

24
Q

chemoprophylaxis for chloroquine-resistant areas (malaria

A

mefloquine, malarone

IM; Re 4 (4 decks)

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