Infectious Disease Small Group

Question 1

neisseria meningitidis

Answer 1

causes streptococci meningitits

• gram negativr diplococci
• extremely potent endotoxin causes severe inflammatory rxn
• rapid bacteremia and sepsis

caused DIC

Question 2

waterhouse-friderichsen snydrome

Answer 2

overwhelming bacterial infection that leads to bilteral adrenal hemorrhage and necrosis. adrenocortical insufficiency results in a lack of adrenaline and noradrenaline

rapid progression to hypotension and shock

DIC leads to purpura

Question 3

high albumin in CSF is indicative of what

Answer 3

leaky BBB, inflammation

Question 4

how does the WBC profile change your differential?

Answer 4

lymphocytes- viral

neutrophil- bacterial

Question 5

what happens to glucose in CSF in bacterial infections

Answer 5

glucose goes to 0 b/c bacteria consume it

Question 6

pathology of herpes encephalitis

Answer 6

extensive lymphocyte infiltrates in brain, lung

looking for herpes inclusion bodies- multinucleated cells w/ clear nuclei

Question 7

CMV histology

Answer 7

owls eye nuclei- causes large, single nucleated cells

Question 8

aspergillis

Answer 8

invasive hyphae fungi- grows into blood vessels in immunocompromised individuals

once in blood, can disseminate throughout body