Infectious disease Epidemics Flashcards

1
Q

how do you define infection

A

Infection is the infiltration of body tissue by micro- organisms (or microbes) that may cause disease, followed by the multiplication of these micro-organisms

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2
Q

How do you define microorganism

A

A micro-organism that can cause disease is called a pathogen

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3
Q

How do you define contagious

A
  • derived from the word contact and describes infections that are transmissible person to person and thus this can also be termed communicable
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4
Q

Whats another word for contagious

A
  • Communicable
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5
Q

virtually all viral diseases are

A

virtually all viral diseases are caused by viruses that are communicable

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6
Q

How can you prevent trachoma

A

clean water and sanitation

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7
Q

What is the commonest cause of blindness

A

Trachoma

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8
Q

name the types of pathogens

A
  • viruses
  • bacteria
  • fungi, protozoa, worms
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9
Q

What are the two types of pathogens

A
  • opportunistic pathogens

- obligate pathogens

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10
Q

What is an opportunistic pathogen

A

Micro-organisms found in healthy host animals that may cause disease in certain circumstances, they take advantage of an “opportunity” not normally available

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11
Q

give examples of opportunistic pathogens

A

Commensals (staphylococcus, streptococcus)

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12
Q

describe opportunistic pathogens

A
  • Cannot infect healthy people (nor do they need to)
  • do so only when illness or injury introduces them to normally sterile parts of the body
  • do not make infected people infectious to other healthy people
  • do not cause epidemics
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13
Q

describe obligate pathogens

A
  • have no reservoir
  • must cause disease to be transmitted from one host to another
  • organisms with no environmental reservoir
  • do infect healthy people - they need to for their own survival
  • make infected people infectious to others - need to for their survival
  • introduced into a susceptible population and will spread from person to person and cause an epidemic
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14
Q

Name the animal sources of human pathogens

  • measles
  • smallpox
  • coronavirus
  • influenza
  • tuberculosis
  • herpes
  • hepaitits B
  • HIV
  • ebola
A
  • measles = dogs, cattle
  • smallpox = cattle (cowpox)
  • coronavirus = cattle, poultry
  • influenza = chickens, swine
  • tuberculosis = cattle (bovine TB)
  • herpes = Monkeys
  • hepaitits B = monkeys
  • HIV = chimpanzees
  • ebola = fruit bats
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15
Q

name some human pathogens that have derived from other human pathogens

A
  • syphilis from bejel

- leprosy from TB

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16
Q

What has caused the pathogens to spread around the world

A
  • human migration carried the organisms around the world
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17
Q

for organisms to survive in the short term what must it do

A
  • cause mild symptoms that will propagate the organism to other humans
  • not to kill humans or make them very ill
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18
Q

Why is it in the interests of the human to develop the symptoms (coughing & sneezing or diarrhoea?)

A
  • To dump live organisms from the body (help out the immune system)
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19
Q

describe examples of conditions that spread by respiratory means

A
  • Measles
  • TB
  • Influenza
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20
Q

What casues respriatory illnesses to spread

A
  • sneezing
  • coughing
  • over-crowding
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21
Q

what illnesses spread by faecal-oral transmission

A
  • polio
  • H pylori
  • rotavirus
  • cholera
22
Q

what casues spread of faecal oral transmission

A
  • Poor sanitation
23
Q

what illnesses spread by sexual transmission

A
  • HPV

- Chlamydia

24
Q

What casues illnesses to sprad by sexual tranmsission

A
  • mutiple partners

- failure to use a condom

25
Q

what illnesses spread by insect vector

A
  • Malaria
  • yellow fever
  • lyme disease
26
Q

What casues illnesses to spread by insect vector

A
  • bare skin
27
Q

what strategies do organisms use to survive in the long term

A
  • continue to infect one susceptible person after another
  • reinfect the same humans by changing its surface antigens so the IgG fails to recognise it
  • find a safe haven in our body - area not accessed by the immune system
28
Q

List organsims that find a safe haven

A
  • Varicella
  • Tubercle
  • Helicobacter pylori
  • typhoid fever
29
Q

hygiene prevents

A

spread of the virus

30
Q

What poeple get post-primary TB

A

Immunocompromised

  • alcoholics
  • homeless
  • old men
31
Q

what diseases are protective of malaria

A
  • sickle cell disease
  • thalassaemia
  • cystic firbosis
32
Q

What is the differnet between the epidemics and endemics

A

Epidemics

  • goes through the community
  • but after a few waves everyone has been infected and it will die out

Endemics

  • infects people slow
  • goes on for longer peroids of time
  • matches the birth rate
33
Q

organisms with no environemental reservoir must…

A

Organisms with no environmental reservoir must infect healthy people, and characteristically do so in epidemics rather than sporadically

34
Q

What are the determinants of the risk of an outbreak in a community

A
  • Susceptible population
  • induction of organsims into community
  • spread fo organisms in the community
35
Q

Name the cholera statistics

A
  • 4 million cases

- 100,000 deaths

36
Q

What are the principles of management of cholera outbreaks

A
  • Clean water - boiled, bottled or chlorinated
  • beware of food washed in water
  • safe disposal of faeces
37
Q

what can increase the severity of the epidemic

A
  • major epidemics of severe illness are generally caused by organisms that are new to the community
  • age
  • nutritional status
  • infecting dose
38
Q

List the major influenza outbreaks

A
  • 1847 - H1N1
  • 1889-90 - H2N2
  • 1899-1900 - Russian - H3N2
  • 1918-20 - Spanish - H1N1 - 40 million dead
  • 1957-60 - Asian - H2N2
  • 1968-72 - Hong Kong - H3N2
39
Q

What is the survival rate of ebola

A
  • 70% with good supportive care (especially IV fluids) but much lower in malnourished people wihtout good care
40
Q

What organism called the bubonic plague

A
  • Yersinia Pestis

- humans contract it from the bites of infected fleas, the fleas live in the fur of the rats

41
Q

describe how EBV is differnet in children and adults

A
  • commonly asymptomatic in children
  • can be debilitating in teenagers and young adults (glandular fever)
  • Contracting the infection in teenage/young adult years may lead to multiple sclerosis
42
Q

the symtpoms that follow an infection…

A

The symptoms that follow an infection are often caused not directly by the organism but by the host response
- e.g. cytokines (host derived peptides released in response to a wide variety of stimuli)

43
Q

Why is case severity greater on average during an epidemic that from sporadic cases

A
  • because during an epidemic a person is oftne infected by two or more people so the infecting dose is greater
44
Q

What cancers can HPV cause

A
  • cervical cancer,

- anal cancer

45
Q

What cancers can EBV cause

A
  • nasopharyngeal cancer, - Burkitt’s lymphoma

- Hodgkin’s lymphoma

46
Q

What cancer can HTLV cause

A
  • T cell leukaemia
47
Q

What cancer can cause Kaposi’s sarcoma virus and associated herpes virus

A

Kaposi’s sarcoma

48
Q

What cancer can cause Helicobacter pylori

A

Stomach cancer

49
Q

what cancer can schistosomiasis cause

A
  • Bladder cancer
50
Q

What cancer can hepatitis B and C cause

A
  • Liver cancer
51
Q

Why is there a higher incidence in developing countries of epidemics

A
  • Poor sanitation
  • Overcrowding
  • Parasites (and mosquitoes) thrive in tropical climates
  • Limited vaccination
52
Q

Why is the case severity worse in developing countries

A
  • Malnutrition
  • overcrowding - high infection dose
  • communal life style - infants under 1 year infected
  • genetic factors in some areas