Infections in the immunocompromised

Question 1

Splenectomy and hyposplenism increase risk of what infections?

Answer 1

Strep pneumoniae
Haem influenzae
Neisseria Meningitis
Capnocytophaga canimorsus

Question 2

Prophylaxis for splenectomy patients?

Answer 2

Amoxyl 250mg daily

Immunisation

Question 3

Infections post transplant?

Answer 3

Viral:
- CMV
- HSV
- CMV
- EBV
Fungal:
- Candida
- Cryptococcus
-Aspergillus
- Nocardia
- TPG
- PCP
Bacteria

Question 4

Infections post cardiac transplant?

Answer 4

Pneumonia
Mediastinitis
CMV
TPG
Nocardia

Question 5

Infections post liver transplant?

Answer 5

Candida
Hepatobiliary sepsis
CMV hepatitis

Question 6

Infections post renal transplant?

Answer 6

UTI
CMV
PCP
BK virus
Fungal

Question 7

Prevention of infections

Answer 7

Valganciclovir
Bactrim
Vaccination

Question 8

Treatment of HHV-6?

Answer 8

Ganciclovir

Question 9

Treatment of EBV post transplant lymphoproliferative disorder?

Answer 9

Mononucleosis, diffuse or extra-nodal

Reduce immunosuppression

Question 10

Presentaiton of pneumocystis?

Treatment?

Answer 10

Pulmonary infection

Bactrim
Corticosteroids

Question 11

Presentation of nocardia?

Treatment?

Answer 11

Cutaneous, Pumonary or systemic

Bactrim
Surgical debridement

Question 12

Presentation of TPG?

Treatment of TPG?

Answer 12

CNS, Myocardial, pulmonary, retinal

Pyrimethamine/folinic acid and sulfadiazine or clindamycin

Question 13

Presentation of candidiasis?

Treatment?

Answer 13

Disseminated candidiasis
Candidaemia

Fluconazole

Question 14

Presentation of aspergillus?

Treatment?

Answer 14

Pulmonary
Cerebral
Aspergilloma

Voriconazole

Question 15

Presentation of cryptococcus?

Treatment?

Answer 15

CNS
Pulmonary
Skin, sinusitis, viscera

Amphotericin B and flucytosine –> fluconazole