Infection part 3 Q 100-150 Flashcards

1
Q

Q100: Examples of cephalosporins

A

1st: Cefalexin, cefradine, cefadroxil…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Q101: How do cephalosporins work?

A

Prevent peptidoglycan buildup.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Q102: Conditions for cephalosporins

A

Septicaemia, pneumonia, meningitis…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Q103: Cephalosporins like which group?

A

Other beta-lactams: Penicillins…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Q104: Cephalosporins side effects

A

Diarrhea, Hypersensitivity…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Q105: Penicillin allergy in cephalosporins

A

1st gene 10%, 3rd gene 2-3%.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Q106: Cephalosporin generations

A

1st, 2nd, 3rd generation, colitis…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Q107: Examples of glycopeptide antibiotics

A

Vancomycin, teicoplanin…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Q108: How do glycopeptide antibiotics work?

A

Inhibit cell wall synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Q109: Uses of glycopeptide antibiotics

A

C.Diff, Endocarditis, MRSA…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Q110: Glycopeptide antibiotics side effects

A

Red man syndrome, Ototoxicity…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Q111: Vancomycin contraindications

A

History of hearing loss.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Q112: Vancomycin route of administration

A

IV preferred, oral for C. diff.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Q113: Vancomycin therapeutic range

A

Pre-dose 10-20mg/L, MIC ≥1mg/L 15-20mg/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Q114: Monitor when taking vancomycin

A

Body weight, serum-vanc conc, FBC…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Q115: Vancomycin drug interactions

A

Nephrotoxicity with aminoglycosides…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Q116: Uses of clindamycin

A

BV, Acne, Diabetic foot infection…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Q117: How does clindamycin work?

A

Slows/stops bacterial growth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Q118: Clindamycin side effects

A

Antibiotic-associated colitis, abdominal pain…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Q119: Clindamycin contraindications

A

Diarrhoeal states.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Q120: Examples of macrolides

A

Erythromycin, Clarithromycin…

22
Q

Q121: How do macrolides work?

A

Bind to ribosomal subunit, inhibit protein synthesis…

23
Q

Q122: Macrolides common scenarios

A

Respiratory & skin infections, pneumonia…

24
Q

Q123: Macrolide common uses

A

Respiratory, skin/soft tissue infections, H. pylori…

25
Q

Q124: Macrolide safety in pregnancy

A

Erythromycin safest, Clarithromycin least safe…

26
Q

Q125: Macrolide drug interactions

A

QT prolongation with various drugs…

27
Q

Q126: Macrolide side effects

A

N+V, diarrhea, GI discomfort…

28
Q

Q127: Azithromycin OTC use and age

A

Treat asymptomatic chlamydia, >16 years old…

29
Q

Q128: Examples of penicillins

A

All end in “cillin”, various types…

30
Q

Q129: Only narrow-spectrum penicillin

A

Penicillin G (Benzylpenicillin)…

31
Q

Q130: How do penicillins work?

A

Interfere with cell wall synthesis…

32
Q

Q131: Common side effect of penicillins

A

Allergy reactions, rash, diarrhea…

33
Q

Q132: Avoid which route for penicillins

A

Subcutaneous in infectious/inflamed sites, intrathecal…

34
Q

Q133: Higher risk of anaphylaxis with penicillins

A

Patients with atopic allergy…

35
Q

Q134: Penicillin contraindication

A

Penicillin allergy, cross sensitivity…

36
Q

Q135: Penicillin G administration route

A

IV preferred due to inactivation by gastric acid…

37
Q

Q136: Route not recommended for Penicillin G

A

Intrathecally, causes encephalopathy…

38
Q

Q137: Electrolyte imbalance with high doses of Penicillin G

A

Hypernatraemia…

39
Q

Q138: Amoxicillin drug interactions

A

WARFARIN, ALLOPURINOL, METHOTREXATE…

40
Q

Q139: Difference between true allergy and side effect

A

Allergic reaction vs. later onset…

41
Q

Q140: Examples of quinolones

A

Ciprofloxacin, Levofloxacin, Moxifloxacin…

42
Q

Q141: How do quinolones work?

A

Inhibit topoisomerases, prevent DNA replication…

43
Q

Q142: Quinolones safety warnings

A

Seizure threshold, tendon damage…

44
Q

Q143: Quinolones important drug interactions

A

NSAIDs, Corticosteroids, drugs prolonging QT…

45
Q

Q144: Quinolones main side effects

A

GI (nausea, dyspepsia), CNS (dizziness)…

46
Q

Q145: Quinolones caution and contraindication

A

Contraindicated in history of tendon damage, caution in MG…

47
Q

Q146: Patient groups to avoid quinolones

A

Children, pregnancy, history of tendon or joint damage…

48
Q

Q147: Examples of tetracyclines

A

Doxycycline, Minocycline, Tetracycline…

49
Q

Q148: How do tetracyclines work?

A

Inhibit protein synthesis, bacteriostatic…

50
Q

Q149: Tetracyclines main side effects

A

Discontinue for intracranial hypertension, NVD, photosensitivity…

51
Q

Q150: Tetracyclines requiring sun protection

A

Doxycycline, Demeclocycline…