infection and response Flashcards

1
Q

What are pathogens? What are the four examples of them?

A

Pathogens are microorganisms that cause an infectious disease. This is only for communicable disease. The examples are protists, viruses, bacteria and fungi.

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2
Q

What is the size of bacteria? How do they cause disease?

A

Bacteria are very small, about 1/100th of body cells. Once they are inside the body, they reproduce rapidly, up to every 20 minutes. They can then produce poisons or toxins that damage tissues to make us feel ill.

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3
Q

What is the size of viruses? How do they cause disease?

A

Viruses aren’t cells, they are 1/100th of bacteria cells. They only reproduce inside a host cell. When they invade a host cell, they reproduce using its DNA, which damages the cell so that it bursts and dies.

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4
Q

How do protists cause disease?

A

Protists are single celled eukaryotes or parasites which live on or in other organisms. They are usually transmitted by a vector, which itself doesn’t get the disease.

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5
Q

How do fungi cause disease?

A

Fungi are single celled or have a body made of hyphae which can grow and penetrate human skin or the surface of plants. They produce spores, which spread from plants and animals.

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6
Q

How do you reduce the spread of disease?

A

reducing spread of disease:

  • washing hands and being hygienic
  • clean drinking water
  • using a condom
  • isolate infected individuals
  • destroy vectors
  • vaccination
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7
Q

What type of disease is measles? Describe the symptoms, the effects and how it is spread.

A

measles:

  • a virus
  • symptoms are fever after 3 days, red rash
  • spread in droplets when infected person coughs or sneezes
  • can damage breathing system and brain
  • children vaccinated
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8
Q

What type of disease is HIV? Describe the symptoms, how it happens, how it is spread and how to stop it (temporarily).

A

HIV:

  • a virus
  • initially it is a flu-like illness, but disappears after a few weeks
  • virus attack immune system which becomes severely damaged until it can’t fight off other infections that are usually easily dealt with or it can’t cope with cancer cells
  • spread by sexual contact or exchanging bodily fluids
  • antiretroviral drugs stop early stage HIV so the immune system is not damaged. this is not a cure, so this must be taken for their entire life
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9
Q

What type of disease is rose black spot? Describe how it is spread, the symptoms and how it is treated.

A

rose black spot:

  • fungal disease
  • causes leaves to develop purple and black spots
  • leaves then turn yellow and drop off
  • spread by water or wind
  • treat by spraying plant with fungicides (chemicals that kill fungi) or remove infected leaves and destroy them
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10
Q

What type of disease is gonorrhoea? Describe the symptoms, how was it originally treated and how you prevent the spread of it.

A

gonorrhoea:

  • bacterial disease
  • sexually transmitted disease
  • symptoms are thick yellow or green discharge from the penis or vagina, and pain when urinating
  • originally treated with antibiotic penicillin, but now some bacteria are resistant to this
  • prevent spread with condom and new antibiotics
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11
Q

What type of disease is tobacco mosaic virus? Describe the symptoms and the treatment.

A

tobacco mosaic virus:

  • viral disease
  • widespread plant pathogen that infects tomatoes etc.
  • causes discolour on leaves in mosaic pattern
  • affects growth as rate of photosynthesis is decreased
  • treatment is removing all infected plants
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12
Q

What type of disease is malaria? Describe the symptoms, how it is spread and how to prevent the spread of it.

A

malaria:

  • protist disease
  • symptoms are repeating episodes of fever which can be fatal
  • infected person is bitten by mosquito, the malaria pathogen passes into the mosquito, which is now the vector. this mosquito multiplies and bites others to pass on the malaria pathogen
  • prevent by stopping vector from breeding (they breed in still water, so drain these areas or spray with insecticide which kills mosquitoes)
  • prevent from biting, so use mosquito net and spraying net with insecticide
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13
Q

What type of disease is salmonella? Describe how it is spread, the symptoms and how to prevent it.

A

salmonella:

  • bacterial disease
  • spread by ingesting infected food, prepared in unhygienic conditions
  • symptoms are fever, abdominal cramps, vomiting and diarrhoea caused by the toxins secreted
  • chicken are vaccinated against salmonella
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14
Q

What are the four non-specific defense systems in the body to prevent pathogens from entering the body?

A

non-specific defense systems:

1) skin
- outer layer is dead cells, difficult for pathogens to penetrate
- produces sebum which kills bacteria
- scabs stop pathogens from entering the bloodstream
2) nose
- hair and mucas to trap pathogens
3) trachea and bronchi
- covered with cilia (hairs) which are covered in mucas, and they waft it to the throat where it’s swallowed into the stomach
4) stomach
- contains hydrochloric acid which kills pathogens before they enter the digestive system

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15
Q

Describe the process of phagocytosis.

A

phagocytosis:

  • white blood cells ingest and destroy pathogens
  • they detect the chemicals released from a pathogen, move towards it, ingest it and use enzymes to destroy it
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16
Q

Describe the process of antibody production.

A

antibody production:

  • antibodies are protein molecules produced by white blood cells
  • every pathogen has unique molecules called antigens on its surface
  • white blood cells produce antibodies specific to the antigen
  • when the antibody meets the antigen, it triggers them to be destroyed
  • the antibody is now rapidly produced and carried around the body
  • they remain in the blood for a long time, so we are naturally immune
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17
Q

What diseases does the MMR vaccination make you immune to?

A

MMR - measles, mumps and rubella (German measles)

18
Q

How does vaccination make individuals immune to a disease?

A

vaccination:

  • introducing dead or inactive, small quantities of pathogens into the body
  • this cannot lead to disease as dead or inactive
  • white blood cells are stimulated to make antibodies
  • they stay in the body for a long time, so will be immune in the future
19
Q

How do antibiotics prevent disease? Which disease do they prevent?

A

antibiotics:

  • ONLY FOR BACTERIA
  • they kill infective bacteria without harming body cells (can’t be used for viruses as will harm body cells)
  • important that they are specific
20
Q

What do painkillers do to pathogens?

A

Painkillers treat the symptoms but they do not kill the pathogens.

21
Q

Why shouldn’t you overuse antibiotics?

A

You shouldn’t overuse antibiotics as it won’t be effective. The bacteria can mutate so that there are strains of bacteria that are resistant to it. This is antibiotic resistance.

22
Q

Where were many drugs originally extracted from?

A

Many drugs are originally extracted from plants, which are the chemicals they use to defend, or microorganisms.

23
Q

Where did the heart drug digitalis originate from?

A

The heart drug digitalis originated from foxgloves plants.

24
Q

Where did the painkiller aspirin originate from?

A

The painkiller aspirin originated from a willow, which lowers fever.

25
Q

Where are most drugs extracted from nowadays?

A

Most drugs today are synthesised by chemists in the pharmaceutical industry, but the starting point is still often a plant.

26
Q

What drug did Alexander Fleming discover? How?

A

Alexander Fleming discovered penicillin in the mould Penicillium. He noticed the area around the mould was free of bacteria.

27
Q

What are the three stages of drug testing?

A

drug testing:

1) preclinical testing
- not tested on humans as could be toxic
- carried out on cells, tissues and animals in the lab

2) clinical testing
- now on humans
- low doses given to healthy volunteers to see if safe
- then, given optimal dose to actual patients
- sometimes, placebo is given as a control variable
- possible for a double blind, so doctors and patients don’t know which is which to stop bias

3) peer review
- prevents false claims, checked then published

28
Q

Describe the process of making monoclonal antibodies.

A

monoclonal antibodies:

1) mouse is injected with the antigen we want antibodies for
2) extract the lymphocytes (white blood cells that produce antibodies) from the mouse
3) select the lymphocytes that produce the desired antibody
4) fuse the lymphocyte with a tumour cell as the antibodies will be produced rapidly
5) this is a hybridoma, which produces monoclonal antibodies that can be collected and purified

29
Q

How can monoclonal antibodies be used in diagnosis in pregnancy tests?

A

pregnancy tests with monoclonal antibodies:

  • urinate on text strip
  • there is antibodies with blue beads attached
  • the hormone HCG (only in urine of pregnant women) binds with the antibodies
  • they move up the stick
  • blue beads and hormone bind to antibodies on the strip, turning it blue
  • if not pregnant, blue beads aren’t triggered
30
Q

How can monoclonal antibodies be used in lab testing?

A

lab testing with monoclonal antibodies:

  • can measure levels of hormones in the blood
  • they detect the pathogens, and they are completely specific so they are always correct
31
Q

How can monoclonal antibodies be used in locating specific molecules in a cell?

A

location with monoclonal antibodies:

  • to locate or identify specific molecules in a cell
  • bind them to a fluorescent dye which is activated by the molecules
32
Q

How can monoclonal antibodies be used in treating cancer? Why is it not widely used yet?

A

treating cancer with monoclonal antibodies:

  • specific to cancer cells
  • attached to a radioactive substance or toxic drug so that when the antibody attaches to the cancer cells, it stops them from dividing
  • it doesn’t harm other cells
  • in some tests, there are harmful side effects so still being tested
33
Q

What are seven common signs of plant disease?

A

common signs of plant disease:

  • stunted growth
  • spots on leaves
  • discolouration
  • decay and rot
  • growths
  • malformed stems and leaves
  • presence of pests
34
Q

What are three ways to identify a plant disease?

A

identifying plant disease:

  • reference to gardening manuals or websites
  • taking infected plants to a lab to identify the pathogen
  • using test kits that contain monoclonal antibodies
35
Q

What are aphids?

A

Aphids are an insect which extracts nutrients from the plant, stunting its growth.

36
Q

Why do plants need nitrate ions?

A

Plants need nitrate ions for protein synthesis, so a lack of them will cause stunted growth.

37
Q

Why do plants need magnesium ions?

A

Plants need magnesium ions to make chlorophyll, so a deficiency in it is identifiable by yellow leaves and is called chlorosis.

38
Q

What are three physical plant defence responses?

A

physical plant defence responses:

  • cellulose cell walls are difficult for microorganisms to penetrate
  • leaves are covered in a waxy cuticle, which is difficult to penetrate
  • layers of dead cells are around the stems (like bark) which is another barrier, and they fall off and are replaced
39
Q

What are two chemical plant defence responses?

A

chemical plant defence responses:

  • they release antibacterial chemicals to kill bacteria
  • they release poisons which deter herbivores from grazing the plant
40
Q

What are three mechanical plant defence responses?

A

mechanical plant defence responses:

  • thorns and hairs stop animals from touching the plant, and hairs irritate the mouth of herbivores, making it difficult to eat
  • leaves may droop or curl when touched which scares herbivores and knocks off insects
  • some plants mimic other organisms to trick animals, like the white dead nettle looks like a stinging nettle but doesn’t sting