Infection

Question 1

What are the hospital treatment for meningitis

Answer 1

Benzylpenicillin
Or
Cefotaxime

Question 2

What are the antibiotics suitable for LOWER urinary tract infection MADCB

Answer 2

Trimethoprim
Nitrofurantoin
Amoxicillin
Oral cephalosporins
For 3-7 d

Question 3

What are the drugs used for tuberculosis

Answer 3

Initial phase 4 drugs 
Isoniazid 
Rifampicin 
Ethambutol 
Pyrazinamide
For 2M

Maintainance phase 2 drugs:
Isoniazid
Rifampicin
For 4M

Question 4

Linezolid spectrum

Answer 4

G+ve only
And anaerobes
MRSA

Question 5

Linezolid used instead of… in MRSA INFECTION

Answer 5

Vancomycin

Question 6

Se of linezolid

Answer 6

Blood disorder
Optic neuropathy if > 28 days use
Hypertensive crisis with SSRI TCA MAOI sumatriptan DA buspirone as linezolid is a reversible MAOI

Question 7

What food to avoid when taking linezolid and why

Answer 7

Tyramine rich food bc linezolid is a reversible MAOI

Question 8

Dose of trimethoprim for UTI

Answer 8

200BD

Question 9

Se of Trimethoprim

Answer 9

1 teratogenic in first trimester as anti-folate
2 Blood dyscrasias with long-term use
3 Hyperkalaemia

Question 10

What is the indication for co-Trimoxazole

Answer 10

Prophylaxis and treatment of pneumocystis jirovecii

Question 11

What’s co trimoxaxole consist of

Answer 11

Trimethoprim / sulfamethoxazole

Question 12

What are the side effects of co trimoxazole

Answer 12

Rash
SJS
photosensitive

Question 13

Nitrofurantoin urine colour

Answer 13

Yellow or brown

Question 14

Antibiotics that need to be taken with food

Answer 14

Metronidazole

Nitrofurantoin

Question 15

Abx used for UTI

Answer 15

1st line nitrofurantoin/ trimethoprim
2nd pivemecillinam (penicillin)
Fosfomycin

Question 16

Gentamicin multiple dose regimen - when to monitor serum level

Answer 16

after 3 or 4 doses or after a dose change

Question 17

gentamicin- how to manage in renal impair pt

Answer 17

increase dosing interval

Question 18

gentamicin- how to manage in SEVERE renal impair pt

Answer 18

reduce dose

Question 19

describe streptomycin

Answer 19

aminoglycoside, used as reserve for TB

Question 20

describe neomycin

Answer 20

the only aminoglycoside that is PARENTALLY TOXIC, only used in bowel sterilisation

Question 21

describe tobramycin

Answer 21

aminoglycoside used via inhaler for pseudo inf in cystic fibrosis - a hereditary disease, ex mucus in airway and GI cause lung inf and poor nutrition

Question 22

abx that most likely to cause GI colitis

Answer 22

clindamycin

Question 23

abx used to trt abx-related colitis (c.diff) and MRSA

Answer 23

vancomycin

Question 24

how to monitor serum vancomycin level

Answer 24

monitor after 3 or 4 doses and after dose change

Question 25

vancomycin pre-dose trough level

Answer 25

10-15mg/ml

Question 26

vancomycin pre-dose trough level for endocarditis or complicated SA inf

Answer 26

15-20mg/ml

Question 27

vancomycin infusion rate must be below x to avoid red man syndrome

Answer 27

< 10mg/ml

Question 28

abx to avoid when trting MRSA

Answer 28

quinolones eg cirpofloxacin

Question 29

s/e of quinolones

Answer 29

1. seizure
2. tendonitis
3. arthropathy
4. QT prolongation