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BNF > DDIs > Flashcards

DDIs Flashcards

1
Q

Cytochrome P450 INDUCERS

A 
SCRAP GPS
St johns wort 
Carbamazepine
Rifampicin
Alcohol 
Phenytoin
Griseofulvin
Phenobarbital
Sulphonylureas
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2
Q

name a few Sulphonylureas

A 
Glibenclamide	
Gliclazide	
Glipizide	
Glimepiride
Tolbutamide
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3
Q

Cytochrome P450 INHIBITORS

A 
SICK FACES . COM
Sodium V
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol + grapefruit juice (amiodarone)
Chloramphenicol 
Erythromycin (marcolids ACE)
Sulphonamides
Ciprofloxacin
Omeprazole
Metronidazole
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4
Q

examples of sulphonamides

A

sulfadiazine, sulfamethizole, sulfamethoxazole, sulfasalazine

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5
Q

Exampled of drugs that commonly interact with cytochrome P450 enzyme inhibitors and inducers are

A 
Warfarin
Combined Contraceptive Pill
Theophylline
Corticosteroids
TCA
Pethidine
Statins
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6
Q

metformin + cimetidine =

A

inhibits renal elimination

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7
Q

gentamycin + loop diuretics

A

renal failure risk

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8
Q

ACEi + K sparring dirutics

A

hyperkaleamia risk

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9
Q

statin + amiodarone

A

A=inhibitor, increase statin conc –>rhabdomyolysis

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10
Q

stain + macrolids

A

Ery= inhibitor rhabdomyolysis –> kidney failure (cannot remove waste released from muscle firber degradation)

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11
Q

thiazide +PPI

A

hypOMagnesaemia

hypONatraemia

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12
Q

thiazide + lithium

A
  • increased lithium level –> toxicity

- hypokalaemia -TdP - cardiac death

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13
Q

drugs with narrow theraputic window

Guys With Large D Totally Make Perfect Internet Connections

A 
Gentamycin
Warfarin
Lithium
Digoxin
Theophylline
Methotraxate
Phenytoin
Insulin
Ciclosporin
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14
Q

Oestrogen positive breast cancer treatment interacts with which drug

A

Paroxetine fluoxetine SSRI decrease Tamo E
warfarin increase anticoagulant
Terbinafine decrease tamo E

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15
Q

Dosing instruction for antiplatelet and the exception

A

Take with or after food

Except dipyridamole MR to be taken one hour before food

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16
Q

Concentration of clopidogrel is reduced by COAF

A

Carbamazepine erythromycins fluconazole Itraconazole Ketoconazole fluoxetine lansoprazole omeprazole

17
Q

Clopidogrel increases the concentration of which drug

A

Rosuvastatin

BNF (13 decks)

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