Induction Drugs

Question 1

Drugs that are derived from:
Barbaturic acid

Answer 1

Barbituates

Question 2

Barbituates Preparation

what is it incompatible with?

Answer 2

Barbiturate Preparation

• Sodium salts in alkaline solution
  
  • pH of 2.5% sodium thiopental = 10.5
• Barbs are weak acids
• pK for STP is 7.6
• > or < 50 non-ionized in plasma?
• Incompatible in solution with opioids, catecholamines and NMBAs –>Precipitates form… can be a huge

problem
¢ Available as racemic mixtures