Induction Agents

Question 1

Which agents are water soluble? Which are not?

Answer 1

Water soluble - thiopental and ketamine

Not propofol/ etomidate

Question 2

Which agent has the shortest and longest initial half life?

Answer 2

Shortest - etomidate 1 min

Longest - ketamine 16 mins

Question 3

Which agent has the shortest terminal half life?

Answer 3

Ketamine - 3 hours

Question 4

Which agent has the longest terminal half life?

Answer 4

Thiopental - 12 hours

Question 5

What is the terminal half life of propofol?

Answer 5

Propofol: 4-7 hours

terminal half life

Question 6

What is the Vd of induction agents?

Answer 6

Etomidate - 5.4
Prop - 4.6
Ketamine - 3
Thiopental- 2.4

Question 7

Which agents have the highest clearance?

Answer 7

Propofol - 25ml/min/kg

Question 8

What is the clearance of thiopental, etomidate and ketamine?

Answer 8

Ketamine- 19

Etomidate- 18

Thiopental- 11

ml/min/kg

Question 9

What are the least and most protein bound induction agents?

Answer 9

Least: Ketamine - 12%

Most: Prop - 98%
Thiopental - 80%
Etomidate - 75%

Question 10

Which induction agent can cause increase in HR?

Answer 10

Thiopental, Ketamine

Question 11

Which induction agents:

1. Reduce contractility?
2. Increase contractility?

Answer 11

1. Decrease contractility: propofol, thiopental

2. Increase contractility: ketamine

Question 12

Agent that reduces SVR/ MAP?

Answer 12

Propofol and thiopental

Question 13

Increase SVR/ MAP?

Answer 13

Ketamine

Question 14

Which depress respiratory system?

Answer 14

Propofol and thiopental

Question 15

Which induction agent can cause bronchodilation?

Answer 15

Ketamine

Question 16

Which induction agents:

1. Reduce CBF?
2. Increase CBF?

Answer 16

1. Reduce CBF- propofol, thiopental, etomidate

2. Increase CBF - Ketamine