Indirect- and mixed acting adrenoceptor agonists

Question 1

Indirect-acting adrenoceptor agonitsts - 3 drugs/substances

Answer 1

Amphetamine.
Tyramine.
Cocaine.

Question 2

Amphetamine - MOA

Answer 2

Inhibits norepinephrine storage in the sympathetic neuron. Increased cytoplasmic NE concentration causes reverse transport into the synapse by catecholamine transporter. Both in CNS and PNS

Question 3

Amphetamine - effects

Answer 3

Vasoconstriction, cardiac stimulation, increased BP, CNS stimulation.

Question 4

Tyramine - source and interaction.

Answer 4

May cause marked increased BP in pts MAO-inhibitors (e-g- for depression).
Found in bananas.

Question 5

Cocaine - MOA

Answer 5

Inhibits catecholamine transporter in presynaptic neuron. Decreased NE reuptake, and increased synaptic NE concentration

Question 6

Cocaine - effects

Answer 6

Vasoconstriction, cardiac stimulation, increased BP, blocks dopamine reuptake.

Question 7

Cocaine - clinical uses

Answer 7

Local anesthesia

Question 8

Cocaine - adverse effects

Answer 8

Ischemia and necrosis og nasal mucosa (abuse).

Severe hypertension.

Question 9

Mixed-acting adrenoceptor agonists - 3 drugs

Answer 9

Dopamine
Ephedrine
Psuedoephedrine

Question 10

Ephedrine - MOA + effects

Answer 10

Activate α1- (vasoconstriction) and β-adrenoceptors (bronchodilation)

Question 11

Ephedrine - adverse effects

Answer 11

Tachycardia.
Hypertension. 
Urinary retention.
CNS stimulation.
Insomnia

Question 12

Psuedoephedrine - special

Answer 12

Used illegally to make methamphetamine.

Question 13

Psuedoephedrine - adverse effects

Answer 13

Tachycardia, urinary retention, CNS stimulation, insomnia.