INBDE - IMPORTANTS Flashcards
Ibuprofen
MOA:
* Inhibitor COX-1 and COX-2 reversible
* Dose max 3.200mg (adults); 2.400 (child)
Side Effects:
* increase risk of bleeding (long
term: partial or total kidneys fail)
Obs.: patient addiction, renal chronic and
drinks alcohol, “Ibuprofeto acentua doença
renal. Prescever Hydrocodone”
*Obs2.: if patient drinks alcohol and has
cirrhosis: Ibuprofen 3.200mg
Acetaminophen
MOA:
* Inhibits COX-1 and COX-2 (Hypothalamus + SNC)
https://www.medicalnewstoday.com/articles/acetaminophen-and-ibuprofen
Naloxone (Narcan)
MOA:
* Reverse opioids
* Mu receptor ANTAgonist
Bupropion (Aplenzin)
MOA:
* Norepinephrine and dopamine reuptake inhibitor
CHARACTERISTICS:
* Major depressive disorder (MDD)
* Seasonal affective disorder (SAD)
* Smoke cessation
SIDE EFFECTS:
* Xerostomia
https://www.medicalnewstoday.com/articles/326372#_noHeaderPrefixedContent
Buspirone
MOA:
* Increase 5-HT1A receptors
CHARACTERISTICS:
* Anxiety and depression
https://www.medicalnewstoday.com/articles/drugs-buspirone-oral-tablet
Benzodiazepines
MOA:
* Enhance gamma-aminobutyric acid (GABA) effects at the GABA-A
Receptors
* Increase GABA binding and chloride ion influx to slow down the
CNS
CHARACTERISTICS:
* Midazolam – short/to child because is IM
* Triazolam – short/adult and child, cooperative, oral
* Diazepam (valium) – long /adult
* Lorazepam – intermediate-acting
Obs.: Diazepam 5mg 1hs before appointment or at bedtime the night before the dental appointment.
Obs.2: Flumazenil reverse benzodiazepine activity
(avoid in pregnancy).
Clonazepam (Klonopin)
MOA:
* Long-acting and high-potency BZDS, acting as a positive allosteric modulator on GABA-A receptors
CHARACTERISTICS:
* Use to control bruxism, seizures, epilepsy and
anxiety
Phenytoin (Dilantin)
MOA:
* Treating and preventing seizures
* Non-specific channel blocker, inhibiting the positive feedback
loop
(shortens QT interval)
SIDE EFFECTS:
* hirsutism
* osteomalacia
* teratogenicity
* megaloblastic anemia
* inhibits insulin release
* gum hypertrophy (gingival hyperplasia)
* vitamin K deficiency
* (Toxic doses: arrhythmia; ataxia; nystagmus;
diplopia)
Carbamazepine (Tegretol)
MOA:
* Anticonvulsant
* Blocks sodium channels
CHARACTERISTICS:
* Trigeminal Neuralgia: act as modulation of
voltage-gated sodium channels, leading to a
decreased in neuronal activity
Methotrexate
- Inhibits of enzymes responsible for nucleotide synthesis (prevent cells division)
CHARACTERISTICS:
* Antineoplast, used treatment: cancer; severe
psoriasis; severe rheumatoid arthritis and
juvenile rheumatoid arthritis
Side effects: dizziness; drowsiness; headache;
swollen (tender gums); decreased appetite;
reddeness eyes; hair loss
