Importante Flashcards

1
Q

Matriz celular del nicho hematopoyetico incluye (9)

A

Adipocitos
Células endoteliales
Células estromales
Células reticulares adventicias
Fibroblastos
Linfocitos
Monocitos/macrófagos
Osteoblastos
Osteoclastos

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2
Q

Adiponectina, colagena, fibronectina, hemonectina, laminina, proteoglicanos, tenascina, trombospondina y vitronectina corresponden a

A

Matriz extracelular del Microambiente hematopoyetico

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3
Q

Componente del estroma que expresa CD45

A

Macrófagos estromales

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4
Q

Como se distinguen los macrófagos estromales

A

MHC II, CD14, CD11 y CD68

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5
Q

La leptina y osteocalcina liberadas por los adipocitos promueven e inhiben:

A

Promueven granulopoyesis y osteogenesis
Inhiben linfopoyesis

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6
Q

Secretan factores estimulantes de colonias de granulocitos, macrófagos, granulocitos-monocitos e IL1 y 6

A

Osteoblastos

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7
Q

Los osteoblastos son el banco primario de

A

Prostaglandinas y vitamina D3 (q.25 hidroxivitamina)

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8
Q

Citocinas secretadas por los osteoblastos para regular la hematopoyesis

A

IL1 y 6, LIF y TNFa

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9
Q

Factores hematopoyeticos de las celulas estromales

A

IL1 y TNF

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10
Q

Factores de crecimiento hematopoyetico de las celulas madre pluripotenciales

A

SCF
FLT3-L
VEGF

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11
Q

Factores de crecimiento hematopoyeticos que actuan en las celulas progenitoras

A

IL3
GM-CSF
IL-6
G-CSF
TPO

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