Important Stuff

Question 1

TCR specificity

Answer 1

• unique specificity
• only interact with self-MHC
• present ONE specific Peptide at a time

Question 2

BCR specificity

Answer 2

• unique specificity
• > specific to ONE epitope
• expresses many identical BCRs
• can present exogenous antigens to Th-cells
• > they are APCs, but can only present antigen that BCR recognizes

Question 3

MHC specificity

Answer 3

• Broad Specificity
• Can bind different peptides, BUT only ONE at a time
• bind antigens, but do not recognize
• > APCs

Question 4

Antibody specificity

Answer 4

• each B cell makes antibodies with ONE antigen binding specificity identical to the BCR of that B-cell
• > have the same variable region in the F(ab) region of the antibody molecule

Question 5

Polyclonal Antibodies

Answer 5

• Pathogen/vaccine has many different epitopes, so there are many different types of Ab made for the pathogen/vaccine
• Antibodies from multiple clones of B cells

Question 6

Monoclonal Antibodies

Answer 6

• Antibody made from a single clone, all being identical with the same epitope recognition

Question 7

Fc Region

Answer 7

• constant region
• determines biological activity of the Ab
• determines the CLASS

Question 8

F(ab) region

Answer 8

• variable region

- determines the antigen specificity of the antibody molecule