APC and Antigens

Question 1

Where would you be most likely to find DCs?

Answer 1

• lymph nodes, skin and mucosa where invaders are

Question 2

BCR on the surface that can recognize soluble antigen

Answer 2

• B-lymphocytes

Question 3

Needs to be acquired and presented to CD4+ helper T- lymphocytes by professional APCs

Answer 3

• exogenous antigens

Question 4

Peptide generated in endosome and or phagosome by lysosomal proteases

Answer 4

• MHC-II antigen processing

Question 5

Antigen presenting cells only. Present phagocytosed antigens to T-helper (CD4+) cells. Extremely important for mature B cell responses (antibodies)

Answer 5

• MHC class 2

Question 6

Peptide transported by TAP

Answer 6

• MHC-I antigen processing

Question 7

Antigen presenting is their only job. 100x more efficient at MHC-II presentation.

Answer 7

• Dendritic cells

Question 8

Infected nucleated cells process and present endogenous antigen via MHC-I molecules to Cytotoxic T lymphocytes (CD8+ T cell)

Answer 8

• Cell-mediated immune response

Question 9

Bind antigen with the BCR and then ingest and process the antigen before presenting it via MHC-II (peptide ONLY) molecules to T- helper cells.

Answer 9

• B lymphocytes as APCs

Question 10

Bind antigen with the BCR which then sends a signal to the B-cell to differentiate into an antibody secreting cell
called a plasma cell. B-cell takes up, processes and presents antigen to a T-helper cell (CD4+)

Answer 10

• B cells as antibody-producing cells

Question 11

Present exogenous antigens to CD4+ T-lymphocytes (T-helper lymphocytes)

Answer 11

• MHC-2 antigen presentation

Question 12

Peptide generated in cytoplasm by proteosome

Answer 12

• MHC-I antigen processing

Question 13

APC process and present exogenous antigen via MHC-II molecules to T helper lymphocytes (CD4+ T cell). T-helper cells can help B cells to make antibody

Answer 13

• humoral immune response

Question 14

Most T-lymphocytes only recognize antigen when bound to ?

Answer 14

• MHC molecules (MHC restriction)

Question 15

Main role is antibody production. Has a B cell receptor (BCR)- membrane bound antibody. BCR is not restricted to protein antigens and can directly bind antigen

Answer 15

• B cells

Question 16

Surface membrane proteins that display both self and non-self antigens for recognition by T lymphocytes

Answer 16

• Major Histocompatibility Complex (MHC) Molecules

Question 17

Must be activated before antigen exposure to present. Can only present to previously sensitized T-helper cells. The Primary APC of the brain and testis

Answer 17

• Macrophages

Question 18

Surface membrane proteins that display both self and non-self antigens for recognition by T lymphocytes (CD4 and CD8)

Answer 18

• Major Histocompatibility Complex (MHC) Molecules

Question 19

The only APC that can present and activate T cells that have never encountered antigen before (naïve T-cells). Thus, they are essential for initiating the primary immune response. Produced from bone marrow stem cells.

Answer 19

• dendritic cells

Question 20

All nucleated cells. Present cytoplasmic antigens to cytotoxic T-cells (CD8+). Important for killing virally infected cells.

Answer 20

• MHC class I

Question 21

TCR on the surface that can recognize linear peptide antigen only in the context of MHC

Answer 21

• T-lymphocytes

Question 22

Present endogenous antigens to CD8+ T- lymphocytes (cytotoxic T-lymphocytes, killer T lymphocytes)

Answer 22

• MHC-I antigen presentation

Question 23

Express on MHC-II and present exogenous antigens

Answer 23

• Antigen presenting Cells
  1. Dendritic Cells
  2. Macrophages
  3. B-cells