Important studies

Question 1

Decimal

Answer 1

patients up to the age of 60, showing benefit of hemicraniectomy in severe MCA ischemic strokes

Question 2

Decimal- 2

Answer 2

patients 60-80 showing improved outcomes with hemicrani in MCA ischemic stroke, but no functional improvment

Question 3

TRANSFUSE

Answer 3

59 centers, 5000 patients randomized got either the freshest blood versus older blood and there was no difference in mortality. organ failure but here was a higher incidence of nonhemolytic febrile reactions in the younger blood. could be cell damage that occurs early on in the storage process

Question 4

ABLE and INFORM trial

Answer 4

not difference in new vs old stored blood

Question 5

PROPPR trial

Answer 5

balanced resuscitation with 1:1:1

Question 6

PRESERVE trial

Answer 6

• no difference in giving any type of fluid for prevention of contrast induced nephropathy
• compared saline v bicarb v NAC in a 2x2 factorial design
• no difference

Question 7

HYDREA study

Answer 7

after PRESERVE showed no difference in CIN with saline or bicarb

Question 8

EDEN trial

Answer 8

looked at 1000 ARDS patients getting full feeds: it showed higher glucose levels, no improvement in mortality of VFD(primary), no rate of difference in cdiff infections

Question 9

ABC- awake and breathing trial 2008 Girard

Answer 9

SAT + SBT better than SBT alone. Decreased MV days and 90 day mortality. More self extubation but no difference in rates of reintubation

Question 10

CRASH trial- TBI

Answer 10

risk of death at 2 weeks and at 6 months was higher in severe TBI patients that were treated with methylprednisolone

Question 11

Eden trial- enteric feeding

Answer 11

provided 25% calories in critical illness and there was no addedd benefit when comapring to full 100% calories

Question 12

Permit trial- enteric feeding

Answer 12

did 40-60% calories, and when comapared to eden trial no added benefit of VFD or mortLITY WHEN COMPARED TO 25% calorie group