Important Info

Question 1

Chondrodysplasias can be caused by problems in:

Answer 1

type 2 collagen, SOX9, IHH, PTHRP, FGFR3, type X collagen, Aggrecan

Question 2

Problems w Collagen X can give you

Answer 2

Osteogenesis Imperfecta

Question 3

Mice lacking _______ form a cartilaginous skeleton that fails to mineralize

Answer 3

RUNX 2

Question 4

Stone man syndrome or Fibrodysplasia ossificans progressiva (FOP) involves mutations in…

Answer 4

BMP

Question 4

Sclerostin is antagonist to what signaling pathway?

Answer 4

Wnt/Beta catenin

Question 5

What cell involves cathepsin K, CLCN7, chlorine channels, etc.

Answer 5

osteoclast

Question 6

During hypertrophy chondrocytes express what type of collagen

Answer 6

type X collagen

Question 7

What are the key regulators of chondrogenesis?

Answer 7

Ihh and PTHrP

Question 8

The disorder of Aggrecan Associated with Chondrodysplasias results in?

Answer 8

extremely short stature

Question 9

Mutations in what gene causes hypophosphatasia (rare heritable rickets)?

Answer 9

TNSALP

Question 10

Type _____ collagen anchoring fibrils to basal lamina

Answer 10

7