Important Cytokines Flashcards
Secreted by Macrophages
1, 2, 3,4, 5, 6, 8, 12, TNF-alpha
1, 2, 3, 4, 5, 6
1 - Fever 2 - stimulates T cells 3 - stimulates BONE marrow 4 - stimulates IgE produciton 5 - stimulates IfA production 6 - stimulates aKute-phase protein production “Hot T-bone stEAK”
1
Causes: Fever and inflammation Activates endothelium to express adhesion molecules Recruits WBCs Activates Osteoclasts
6
Fever and acute phase proteins
8
Chemotactic factor for neutrophils “Clean up on aisle 8”-Neutrophils are recruited to clear infections
12
Tcells –> Th1 Activates NK cells
Tumor necrosis factor Alpha
Activates endothelium Recruits WBCs Vascular leak Maintains granulomas in TB Causes wasting (cachexia) in cancer
Secreted by ALL T-Cells
2, 3
2
Growth of helper, cytotoxic, Tregs, NK cells
3
Support growth and differentiation of bone marrow stem cells (like GM-CSF)
From Th1 Cells
Inerferon-gamma
Interferon-gamma
Secreted by NK cells and T cells in response to IL-12 from macrophages Stims macrophages to kill phagocytosed pathogens Inhibits differentiation of Th2 cells Activates NK cells to kill virus infected cells Increased MHC expresion on all cells
From Th2 cells
4, 5, 10
4
Induces differentiation of T cells to Th (helper) 2 cells Promotes growth of B cells Enhances class switching to IgE and IgG Ain’t too proud “2 BEG 4 help)
5
Promotes growth and differentiation of B cells Enhances class switching to IgA Stimulates growth and differentiation of eosinophils
