Complement

Question 1

Classic

Answer 1

C1, C2b, C3 convertase, C3b, C5, C5b9 (Membrane Attack Complex MAC)
IgG or IgM mediated (“GM makes classic cars”)

Question 2

Alternative

Answer 2

C3, C5, C5b9 (Membrane Attack Complex MAC)
microbe
Microbe surface molecules

Question 3

Lectin (Mannose)

Answer 3

C4, C3b, C5b9 (Membrane Attack Complex MAC)

Mannose or other sugars on microbe surface

Question 4

C3b

Answer 4

Opsonization

“c3B Binds Bacteria”

Question 5

C3a, C4a (only on Mannose pathway), C5a

Answer 5

Analphylaxis (all the “a”=A)

Question 6

C5a

Answer 6

Neutrophil chemotaxis

Given off by all pathways before MAC

Question 7

c5b9

Answer 7

Membrane Attack Complex (MAC)

cytolysis by MAC

Question 8

Early complement deficiences

Answer 8

C1-C4
Increased risk severe, recurrent pyogenic sinus and resp tract infections
Increased risk of SLE

Question 9

Terminal complement deficiencies

Answer 9

C5-C9

Increased risk of Neisseria bacteremia

Question 10

C1 esterase inhibitor deficiency

Answer 10

Causes hereditary angioedema due to increased bradykinin
Decreased C4 levels
ACE are Contraindicated

Question 11

Paroxysmal nocturnal hemoglobinuria

Answer 11

Complement mediated lysis of RBCs

Complement inhibitors can’t anchor (PIGA gene defect)