Differentiation of T-Cells

Question 1

Th1

Answer 1

+ IL-12, IFN-Y
- IL-4, IL-10

Function: Activates macrophages and cytotoxic T-cells to kill phagocytosed microbes
Secretes: IFN-Ygamma
Immunodeficiency: Mendelian susceptibility to mycobacterial disease

Question 2

Th2

Answer 2

+ IL-2, IL-4
- IFN-Ygmma

Function: Activate eosinophils and promote production of IgE for parasite defense
Secretes: IL-4 (amplifies self?), IL-5, IL-6 (activates Th17?), IL-10, IL-13
Immunodeficiency:

Question 3

Th17

Answer 3

+ TGF-Beta, IL-6

Function: Immunity against extracellular microbes, through induction of neutrophilic inflammation
Secretes: IL-17, IL-21, IL-22
Immunodeficiency: Hyper-IgE syndrome

Question 4

Treg

Answer 4

+ TGF-Beta

Function: Prevent autoimmunity by maintaining tolerance to self-antigens
Secretes: TGF-Beta, IL-10 (inhibits Th1?), IL-35
Immunodeficiency: IPEX