Important Cytokines Flashcards
1
Q
What cells release IL-1
A
Activated macrophages, B cells
2
Q
What cells release IL-6
A
T cells, Macrophages, B cells, Fibroblasts
3
Q
What cells release TNF (alpha and beta)
A
Macrophages
4
Q
What cells release IFN (alpha and beta)
A
Mast cells
5
Q
What cells release IL-17
A
Th17 cells
6
Q
What cells release TGF
A
Macrophages, T regulatory cells
7
Q
What cells release IL-2
A
CD4 and CD8 T Helper cells (Th1)
8
Q
What cells release IL-3
A
Activated T cells
9
Q
What is the function of IL-1
A
Promotes inflammation and T cell activation, Causes fever (acts as a pyrogen)
10
Q
What is the function of IL-6
A
- Stimulates leukocytes and production of acute phase proteins in liver, recruitment of neutrophils, differentiates TFH and Th17 cells
- Induces B cells to differentiate into plasma cells (Ab forming cells)
11
Q
What is the function of IL-12
A
- Stimulates Tc and NK cell activity
- Promotes Th1 differentiation
12
Q
What is the function of TNFalpha/beta
A
- Promotes inflammation by enhancing phagocyte chemotaxis and nonspecific killing
- Slows tumour growth by selectively damaging tumour blood vessels
- Promotes apoptosis
13
Q
What is the function of IFN
A
- Antiviral effects
- Activates NK cells
- Activates macrophages
- Stimulates synthesis and expression of more MHC1/MHC2 proteins
- Promotes differentiation of Th to Th1
