Important Cytokines Flashcards by Steven Marincel

Q

What is the function of IF-gamma?

A

induces Th1, inhibits Th17

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Q

What is the function of IL-1?

A

Pro-inflammatory

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Q

What is the function of IL-2?

A

T-cell proliferation, T-Reg survival

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Q

What is the function of IL-4?

A

Ab immunity, inhibits Th17

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Q

What is the function of IL-6?

A

Innate immunity, B cell growth, induction of Th17

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Q

What is the function of IL-8?

A

Pro-inflammatory, major neutrophil chemokine

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Q

What is the function of IL-10?

A

Suppression of some inflammatory pathways

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Q

What is the function of IL-12?

A

Induction of Th1

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Q

What is the function of IL-21?

A

Proliferation of Th1, Th2, and Th17

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Q

What is the function of IL-23?

A

Th17 expansion and stabilization

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Q

What is the function of TNF-alpha?

A

Pro-inflammatory

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Q

What is the function of TGF-beta?

A

Induction of Th17 or T-Regs

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Q

What is the function of RANKL?

A

Stimulates osteoclasts via RANK receptor

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Q

What is the function of Osteoprotegerin?

A

Soluble decoy, modulates RANK/RANKL system

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Q

What cytokines induct Th17?

A

IL-6, IL-12, TGF-beta

IL-21 proliferation, IL-23 stabilization/expansion

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Q

What cytokines inhibit Th17?

A

IF-gamma, IL-4

Q

What cytokines are pro-inflammatory?

A

IL-1, IL-8, TNF-alpha

Q

What is the main cell source of IF-gamma?

A

Th1, NK, NKT cells

Q

What is the main source of IL-1?

A

M/M, other cells

Q

What is the main source of IL-2?

A

Th1 cells

Q

What is the mains source of IL-4?

A

Th2 cells

Q

What is the main source of IL-6?

A

M/M, other cells

Q

What is the main source of IL-8?

A

M/M, other cells

Q

What is the main source of IL-10?

A

DC, M/M, Th2, T-regs

Q

What is the main source of IL-12?

A

M/M, DC

Q

What is the main source of IL-21?

A

Th1, Th2, Th17

Q

What is the main source of IL-23?

A

DC, M/M

Q

What is the main source of TNF-alpha?

A

DC, M/M

Q

What is the main source of TGF-beta?

A

Many cells

Q

What is the main source of RANKL?

A

Osteoid cells, many others

Q

What is the main source of osteoprotegerin?

A

Osteoblasts, T cells

Q

What cytokines are released by M/Ms?

A

IL-1, IL-6, IL-8, IL-10, IL-12, IL-23, TNF-alpha